ArticlePloS one2014
Effects of maternal exposure to ultrafine carbon black on brain perivascular macrophages and surrounding astrocytes in offspring mice.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Exploring the Potential Impact of Nanoparticles on Fetal Development: An Updated Review.Medicina (Kaunas, Lithuania) · 2026Review
- Long non-coding RNAs potentially suppressive for brain perivascular astrogliosis induced by environmental ultrafine particulate matter.Environmental science and pollution research international · 2025Article
- The Effects of Air Pollution on Neurological Diseases: A Narrative Review on Causes and Mechanisms.Toxics · 2025Review
- Carbonaceous Nanoparticle Air Pollution: Toxicity and Detection in Biological Samples.Nanomaterials (Basel, Switzerland) · 2022Review
- A Novel Staining Method for Detection of Brain Perivascular Injuries Induced by Nanoparticle: Periodic Acid-Schiff and Immunohistochemical Double-Staining.Frontiers in toxicology · 2022Article
- Fetotoxicity of Nanoparticles: Causes and Mechanisms.Nanomaterials (Basel, Switzerland) · 2021Review
- Effect of Carbon Black Nanoparticle on Neonatal Lymphoid Tissues Depending on the Gestational Period of Exposure in Mice.Frontiers in toxicology · 2021Article
- Potential of NRF2 Pathway in Preventing Developmental and Reproductive Toxicity of Fine Particles.Frontiers in toxicology · 2021Article
- Carbon nanoparticles induce endoplasmic reticulum stress around blood vessels with accumulation of misfolded proteins in the developing brain of offspring.Scientific reports · 2020Article
- Particle toxicology and health - where are we?Particle and fibre toxicology · 2019Review
- Effects of neonatal inhalation exposure to ultrafine carbon particles on pathology and behavioral outcomes in C57BL/6J mice.Particle and fibre toxicology · 2019Article
- Vessel-Associated Immune Cells in Cerebrovascular Diseases: From Perivascular Macrophages to Vessel-Associated Microglia.Frontiers in neuroscience · 2019Review
- Maternal inhalation of carbon black nanoparticles induces neurodevelopmental changes in mouse offspring.Particle and fibre toxicology · 2018Article
- Nanoparticulate titanium dioxide-inhibited dendritic development is involved in apoptosis and autophagy of hippocampal neurons in offspring mice.Toxicology research · 2017Article
- Dose-dependent induction of astrocyte activation and reactive astrogliosis in mouse brain following maternal exposure to carbon black nanoparticle.Particle and fibre toxicology · 2017Article
- Perivascular Accumulation of β-Sheet-Rich Proteins in Offspring Brain following Maternal Exposure to Carbon Black Nanoparticles.Frontiers in cellular neuroscience · 2017Article
- Traffic-related air pollution and brain development.AIMS environmental scienceArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Perivascular macrophages (PVMs) constitute a subpopulation of resident macrophages in the central nervous system (CNS). They are located at the blood-brain barrier and can contribute to maintenance of brain functions in both health and disease conditions. PVMs have been shown to respond to particle substances administered during the prenatal period, which may alter their phenotype over a long period. We aimed to investigate the effects of maternal exposure to ultrafine carbon black (UfCB) on PVMs and astrocytes close to the blood vessels in offspring mice. Pregnant mice were exposed to UfCB suspension by intranasal instillation on gestational days 5 and 9. Brains were collected from their offspring at 6 and 12 weeks after birth. PVM and astrocyte phenotypes were examined by Periodic Acid Schiff (PAS) staining, transmission electron microscopy and PAS-glial fibrillary acidic protein (GFAP) double staining. PVM granules were found to be enlarged and the number of PAS-positive PVMs was decreased in UfCB-exposed offspring. These results suggested that in offspring, "normal" PVMs decreased in a wide area of the CNS through maternal UfCB exposure. The increase in astrocytic GFAP expression level was closely related to the enlargement of granules in the attached PVMs in offspring. Honeycomb-like structures in some PVM granules and swelling of astrocytic end-foot were observed under electron microscopy in the UfCB group. The phenotypic changes in PVMs and astrocytes indicate that maternal UfCB exposure may result in changes to brain blood vessels and be associated with increased risk of dysfunction and disorder in the offspring brain.
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