ArticleSexually transmitted diseases2014
Bacterial vaginosis and season, a proxy for vitamin D status.
Article in Sexually transmitted diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02558179 (Prospective Multicenter Cross Sectional Study of the American International Biotechnology), which is not on this map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prospective Multicenter Cross Sectional Study of the American International Biotechnology (AIBiotech) Gynecologene Test for the Evaluation of Bacterial Vaginosis/Vaginitis in Symptomatic Women
Who cites it
13 citing papers in PubMed, 16 citations in OpenAlex.
- A blinded, randomized controlled trial of high-dose vitamin D supplementation to reduce recurrence of bacterial vaginosis.American journal of obstetrics and gynecology · 2014Trial
- Prevalence, seasonal patterns, and microbial co-occurrence of selected genital tract microorganisms in women attending a gynecological counseling service in Southern Italy.BMC infectious diseases · 2026Article
- Clinical epidemiology and associations between HPV infection and vaginal infections in Jinan, China: a cross-sectional analysis.Frontiers in cellular and infection microbiology · 2026Article
- Association between bacterial vaginosis and 25-Hydroxy vitamin D: a case-control study.BMC infectious diseases · 2023Article
- Bacterial vaginosis: a review of approaches to treatment and prevention.Frontiers in reproductive health · 2023Review
- Is prenatal diet associated with the composition of the vaginal microbiome?Paediatric and perinatal epidemiology · 2022Article
- Vitamin D deficiency increases the risk of bacterial vaginosis during pregnancy: Evidence from a meta-analysis based on observational studies.Frontiers in nutrition · 2022Article
- Reviewing the Composition of Vaginal Microbiota: Inclusion of Nutrition and Probiotic Factors in the Maintenance of Eubiosis.Nutrients · 2020Review
- Associations between dietary micronutrient intake and molecular-Bacterial Vaginosis.Reproductive health · 2019Article
- Serum 25-Hydroxyvitamin D and Risk of Self-Reported Bacterial Vaginosis in a Prospective Cohort Study of Young African American Women.Journal of women's health (2002) · 2018Article
- Vaginal Microbiome and Its Relationship to Behavior, Sexual Health, and Sexually Transmitted Diseases.Obstetrics and gynecology · 2017Review
- Serum vitamin D status and bacterial vaginosis prevalence and incidence in Zimbabwean women.American journal of obstetrics and gynecology · 2016Article
- Role of Vitamin D in urogenital health of geriatric participants.Journal of mid-life healthArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundLow serum vitamin D concentration has been associated with increased prevalence of bacterial vaginosis (BV) among pregnant women, but the few studies conducted in nonpregnant women have produced inconsistent results. Because serum vitamin D concentration is generally higher in the summer and fall than winter and spring, if vitamin D insufficiency causes BV, then BV would be expected to be more common during seasons with lower vitamin D concentrations.
methodsThe Longitudinal Study of Vaginal Flora followed up women in Birmingham, Alabama (33.5° latitude), quarterly for up to 1 year. We used a case-crossover design with conditional logistic regression among women who attended visits in each season, to assess the adjusted association between season and BV. We compared each woman's BV status in summer, fall, and spring to her own status in winter.
resultsAmong the 3620 women in the parent study, 2337 attended visits in each season; BV prevalence was 40% in winter, 38% in spring, and 41% in summer and fall. One thousand three hundred thirty-five women had BV at some but not all visits and were therefore included in the case-crossover analysis. Season was not associated with BV in women who were BV negative at study entry (odds ratio vs. winter were 1.0 for spring, 1.0 for summer, and 0.9 for fall; P = 0.81). Among women BV positive at study entry, the corresponding odds ratios were 0.9, 1.4, and 1.4 (P < 0.001).
conclusionsThese results do not support an association between vitamin D, measured through the proxy variable of season, and BV.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.