ArticlePLoS computational biology2014
Sensing membrane stresses by protein insertions.
Article in PLoS computational biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
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- Endoplasmic reticulum disruption stimulates nuclear membrane mechanotransduction.Nature cell biology · 2026Article
- Helical sensors of membrane saturation: Changes in orientation and curvature preference.Biophysical journal · 2025Article
- Charge distribution and helicity tune the binding of septin's amphipathic helix domain to membranes.Biophysical journal · 2025Article
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- Congenital myopathies: pathophysiological mechanisms and promising therapies.Journal of translational medicine · 2024Review
- Amphipathic Helices Can Sense Both Positive and Negative Curvatures of Lipid Membranes.The journal of physical chemistry letters · 2024Article
- Magainin 2 and PGLa in bacterial membrane mimics IV: Membrane curvature and partitioning.Biophysical journal · 2022Article
- A mechanical-thermodynamic model for understanding endocytosis of COVID-19 virus SARS-CoV-2.Proceedings of the Institution of Mechanical Engineers. Part C. Journal of mechanical engineering science · 2022Article
- Spontaneous local membrane curvature induced by transmembrane proteins.Biophysical journal · 2022Article
- A synergy between mechanosensitive calcium- and membrane-binding mediates tension-sensing by C2-like domains.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
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- Tricalbin-Mediated Contact Sites Control ER Curvature to Maintain Plasma Membrane Integrity.Developmental cell · 2019Article
- Directed Supramolecular Organization of N-BAR Proteins through Regulation of H0 Membrane Immersion Depth.Scientific reports · 2018Article
- Membrane Curvature Sensing by Amphipathic Helices: Insights from Implicit Membrane Modeling.Biophysical journal · 2018Article
- Article
- Characterizing Residue-Bilayer Interactions Using Gramicidin A as a Scaffold and Tryptophan Substitutions as Probes.Journal of chemical theory and computation · 2017Article
- Membrane Curvature and Lipid Composition Synergize To Regulate N-Ras Anchor Recruitment.Biophysical journal · 2017Article
- Interdigitation between Triglycerides and Lipids Modulates Surface Properties of Lipid Droplets.Biophysical journal · 2017Article
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2 authors.
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Abstract
Protein domains shallowly inserting into the membrane matrix are ubiquitous in peripheral membrane proteins involved in various processes of intracellular membrane shaping and remodeling. It has been suggested that these domains sense membrane curvature through their preferable binding to strongly curved membranes, the binding mechanism being mediated by lipid packing defects. Here we make an alternative statement that shallow protein insertions are universal sensors of the intra-membrane stresses existing in the region of the insertion embedding rather than sensors of the curvature per se. We substantiate this proposal computationally by considering different independent ways of the membrane stress generation among which some include changes of the membrane curvature whereas others do not alter the membrane shape. Our computations show that the membrane-binding coefficient of shallow protein insertions is determined by the resultant stress independently of the way this stress has been produced. By contrast, consideration of the correlation between the insertion binding and the membrane curvature demonstrates that the binding coefficient either increases or decreases with curvature depending on the factors leading to the curvature generation. To validate our computational model, we treat quantitatively the experimental results on membrane binding by ALPS1 and ALPS2 motifs of ArfGAP1.
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