ArticleAJNR. American journal of neuroradiology2014
Brain structure and function in patients after metal-on-metal hip resurfacing.
Article in AJNR. American journal of neuroradiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Hair, serum and urine chromium levels in children with cognitive defects: A systematic review and meta-analysis of case control studies.Chemosphere · 2022Pooled it
- Pooled it
- Cobalt and titanium levels in the brain are associated with Alzheimer's disease pathology but not cognition: A study of older adults with and without total joint replacement.Acta biomaterialia · 2026Article
- Long-Term Risk of Dementia up to Three Decades After Total Joint Arthroplasty: A Population-Based Cohort Study.The Journal of arthroplasty · 2026Article
- Assessment of Essential and Toxic Element Levels in the Toenails of Children with Autism Spectrum Disorder.Biological trace element research · 2025Article
- Metal Concentrations in Blood and Cerebrospinal Fluid of Patients With Arthroplasty Implants.JAMA network open · 2025Article
- Article
- Employing a Toxic Aging Coin approach to assess hexavalent chromium (Cr[VI])-induced neurotoxic effects on behavior: Heads for age differences.Toxicology and applied pharmacology · 2024Article
- Correlation of Blood Metal Concentrations with Cognitive Scores and Neuroimaging Findings in Patients with Total Joint Arthroplasty.Journal of Alzheimer's disease : JAD · 2023Article
- The association of cobalturia with cobaltism symptoms a prospective blinded study of 229 post-arthroplasty patients.PloS one · 2023Article
- Trace Element Changes in the Plasma of Autism Spectrum Disorder Children and the Positive Correlation Between Chromium and Vanadium.Biological trace element research · 2022Article
- Long-term Cognitive Trajectory After Total Joint Arthroplasty.JAMA network open · 2022Article
- Current understanding of hexavalent chromium [Cr(VI)] neurotoxicity and new perspectives.Environment international · 2022Review
- Psychiatric Disorders and Genotoxicity Following Primary Metal on Polyethylene Total Hip Arthroplasty and Their Correlation to Cobalt/Chromium Levels.Drug, healthcare and patient safety · 2022Article
- Parkinsonism in a Patient With Metal on Metal Total Hip Replacement Related Elevated Serum Heavy Metal Levels.Cureus · 2021Article
- Prevalence of Cobalturia Among Adults With Joint Replacements.JAMA network open · 2021Article
- The contribution of the histopathological examination to the diagnosis of adverse local tissue reactions in arthroplasty.EFORT open reviews · 2021Review
- Corrosion of Polished Cobalt-Chrome Stems Presenting as Cobalt Encephalopathy.Arthroplasty today · 2020Article
- F-18 FDG PET brain imaging in symptomatic arthroprosthetic cobaltism.European journal of nuclear medicine and molecular imaging · 2020Article
- Redox toxicology of environmental chemicals causing oxidative stress.Redox biology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeHip prostheses that use a metal-on-metal articulation expose the brain to elevated metal concentrations that, in acute excess due to prosthesis malfunction, is associated with neurologic damage, including visual and hearing loss and motor deficits. Here, we examined whether chronic exposure to lower elevated metal levels, typical of well-functioning prostheses, also affects brain structure and function. MATERIALS AND
methodsWe compared brain volumes, metal deposition, and gray matter attenuation by MR imaging and clinical neurologic function in patients 8 years after receiving a metal-on-metal hip resurfacing versus a matched group of patients with the same duration exposure to a conventional hip prosthesis.
resultsTwenty-nine patients (25 men; mean, age 59±7 years) after metal-on-metal hip resurfacing and 29 patients (25 men; 59±8 years) after total hip arthroplasty were compared. Whole blood cobalt and chromium concentrations were 5-10 times higher in the metal-on-metal hip resurfacing group (P<.0001). Occipital cortex gray matter attenuation tended to be lower (P<.005 uncorrected, P>.05 corrected), and the optic chiasm area tended to be lower (mean difference, -2.7 mm2; P=.076) in the metal-on-metal hip resurfacing group. Subgroup analyses in 34 patients (17 per group), after exclusion of primary ocular pathology, showed the same trend in gray matter attenuation in the occipital cortex and basal ganglia and a smaller optic chiasm in the metal-on-metal hip resurfacing group (mean difference, -3.9 mm2; P=.048). No other structural or functional differences were found between the groups.
conclusionsChronic exposure to metal-on-metal hip resurfacing is associated with subtle structural change in the visual pathways and the basal ganglia in asymptomatic patients.
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Registered trials
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