Evidence map›Paper›PMID 24722280›Full record

ArticleCell death & disease2014

Downregulation of FAP suppresses cell proliferation and metastasis through PTEN/PI3K/AKT and Ras-ERK signaling in oral squamous cell carcinoma.

H Wang, Q Wu, Z Liu, X Luo, Y Fan, Y Liu, Y Zhang, S Hua, Q Fu, M Zhao and 3 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03444987 (A Novel Insight Into the Role of Fibroblast Activation and Autophagy in Uterine Fibroid), which is not on this map. Cited by 116 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
116citing papers in PubMed, 2 pooled it
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03444987 completednot on this mapstarted 2018, after this paper: background citation

A Novel Insight Into the Role of Fibroblast Activation and Autophagy in Uterine Fibroid

TypeobservationalSponsorAssiut UniversityRan2018 to 2020Enrolled35ConditionsUterine FibroidArmsMeasurement of protein expression in tissues.
3 · Its place in the literature

Who cites it

116 citing papers in PubMed, 2 syntheses or guidelines pooled it, 179 citations in OpenAlex.

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56 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

H Wang1] Department of Stomatology of Nanfang Hospital, Southern Medical University, Guangzhou, PR China [2] Cancer Research Institute, School of Basic Medicine, Southern Medical University, Guangzhou, PR China.
Q WuCancer Research Institute, School of Basic Medicine, Southern Medical University, Guangzhou, PR China.
Z Liu1] Cancer Research Institute, School of Basic Medicine, Southern Medical University, Guangzhou, PR China [2] Department of Pathology, School of Basic Medicine, Guangzhou Medical University, Guangzhou, PR China.
X LuoCancer Research Institute, School of Basic Medicine, Southern Medical University, Guangzhou, PR China.
Y FanCancer Research Institute, School of Basic Medicine, Southern Medical University, Guangzhou, PR China.
Y LiuCancer Research Institute, School of Basic Medicine, Southern Medical University, Guangzhou, PR China.
Y ZhangCancer Research Institute, School of Basic Medicine, Southern Medical University, Guangzhou, PR China.
S HuaCancer Research Institute, School of Basic Medicine, Southern Medical University, Guangzhou, PR China.
Q FuCancer Research Institute, School of Basic Medicine, Southern Medical University, Guangzhou, PR China.
M ZhaoCancer Research Institute, School of Basic Medicine, Southern Medical University, Guangzhou, PR China.
Y ChenCancer Research Institute, School of Basic Medicine, Southern Medical University, Guangzhou, PR China.
W Fang1] Department of Stomatology of Nanfang Hospital, Southern Medical University, Guangzhou, PR China [2] Cancer Research Institute, School of Basic Medicine, Southern Medical University, Guangzhou, PR China.
X Lv1] Department of Stomatology of Nanfang Hospital, Southern Medical University, Guangzhou, PR China [2] Cancer Research Institute, School of Basic Medicine, Southern Medical University, Guangzhou, PR China.
Southern Medical University · CNNanfang Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is largely recognized that fibroblast activation protein (FAP) is expressed in cancer-associated fibroblasts (CAFs) of many human carcinomas. Furthermore, FAP was recently also reported to be expressed in carcinoma cells of the breast, stomach, pancreatic ductal adenocarcinoma, colorectum, and uterine cervix. The carcinoma cell expression pattern of FAP has been described in several types of cancers, but the role of FAP in oral squamous cell carcinoma (OSCC) is unknown. The role of endogenous FAP in epithelium-derived tumors and molecular mechanisms has also not been reported. In this study, FAP was found to be expressed in carcinoma cells of OSCC and was upregulated in OSCC tissue samples compared with benign tissue samples using immunohistochemistry. In addition, its expression level was closely correlated with overall survival of patients with OSCC. Silencing FAP inhibited the growth and metastasis of OSCC cells in vitro and in vivo. Mechanistically, knockdown of FAP inactivated PTEN/PI3K/AKT and Ras-ERK and its downstream signaling regulating proliferation, migration, and invasion in OSCC cells, as the inhibitory effects of FAP on the proliferation and metastasis could be rescued by PTEN silencing. Our study suggests that FAP acts as an oncogene and may be a potential therapeutic target for patients with OSCC.

Indexed as

Down-RegulationMAP Kinase Signaling SystemAnimalsCarcinoma, Squamous CellCell CycleCell MovementCell ProliferationEndopeptidasesEpithelial-Mesenchymal TransitionFemaleFibroblast Activation Protein AlphaGelatinasesGene Expression Regulation, NeoplasticGene Knockdown TechniquesGene SilencingHumansEndopeptidasesFibroblast Activation Protein AlphaGelatinasesMatrix MetalloproteinasesMembrane ProteinsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktPTEN PhosphohydrolasePTEN protein, humanras ProteinsSerine Endopeptidases

Identifiers

PMID24722280
PMCPMC5424105
OpenAlexW2056950988

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.