ArticleNature communications2014
Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.
Article in Nature communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 82 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
82 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genomic insights and advanced machine learning: characterizing autism spectrum disorder biomarkers and genetic interactions.Metabolic brain disease · 2024Pooled it
- DeepISO: deep learning-powered prediction of protein-protein interaction rewiring generated by alternative splicing.Genome biology · 2026Article
- Xp22.33 Duplication Encompassing PAR1 in a Male with Syndromic Neurodevelopmental Disorder and Tall Stature.Genes · 2026Article
- A spatial long-read approach at near-single-cell resolution reveals developmental regulation of splicing and polyadenylation sites in distinct cortical layers and cell types.Nature communications · 2025Article
- The coming era of proteomics-driven precision medicine.National science review · 2025Review
- Circadian clock crosstalks with autism.Brain and behavior · 2023Article
- The Molecular and Function Characterization of Porcine MID2.Animals : an open access journal from MDPI · 2023Article
- Increased NMDARs in neurons and glutamine synthetase in astrocytes underlying autistic-like behaviors ofiScience · 2023Article
- Prioritizing genes associated with brain disorders by leveraging enhancer-promoter interactions in diverse neural cells and tissues.Genome medicine · 2023Article
- Review
- Convergent coexpression of autism-associated genes suggests some novel risk genes may not be detectable in large-scale genetic studies.Cell genomics · 2023Article
- Neuronal protein interaction networks in autism spectrum disorder.Cell genomics · 2023Article
- Network Biology and Medicine to Rescue: Applications for Retinal Disease Mechanisms and Therapy.Advances in experimental medicine and biology · 2023Article
- Prioritizing de novo autism risk variants with calibrated gene- and variant-scoring models.Human genetics · 2022Article
- Uncovering the impacts of alternative splicing on the proteome with current omics techniques.Wiley interdisciplinary reviews. RNA · 2022Review
- Barcode fusion genetics-protein-fragment complementation assay (BFG-PCA): tools and resources that expand the potential for binary protein interaction discovery.Nucleic acids research · 2022Article
- Scaffold Protein Lnx1 Stabilizes EphB Receptor Kinases for Synaptogenesis.Frontiers in molecular neuroscience · 2022Article
- Full-length isoform transcriptome of the developing human brain provides further insights into autism.Cell reports · 2021Article
- The impact of age on genetic risk for common diseases.PLoS genetics · 2021Article
- Identification of key modules and hub genes in glioblastoma multiforme based on co-expression network analysis.FEBS open bio · 2021Article
22 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
30 authors.
Funding
Abstract
Increased risk for autism spectrum disorders (ASD) is attributed to hundreds of genetic loci. The convergence of ASD variants have been investigated using various approaches, including protein interactions extracted from the published literature. However, these datasets are frequently incomplete, carry biases and are limited to interactions of a single splicing isoform, which may not be expressed in the disease-relevant tissue. Here we introduce a new interactome mapping approach by experimentally identifying interactions between brain-expressed alternatively spliced variants of ASD risk factors. The Autism Spliceform Interaction Network reveals that almost half of the detected interactions and about 30% of the newly identified interacting partners represent contribution from splicing variants, emphasizing the importance of isoform networks. Isoform interactions greatly contribute to establishing direct physical connections between proteins from the de novo autism CNVs. Our findings demonstrate the critical role of spliceform networks for translating genetic knowledge into a better understanding of human diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.