ReviewCurrent opinion in endocrinology, diabetes, and obesity2014
Testosterone, aging and survival: biomarker or deficiency.
Review in Current opinion in endocrinology, diabetes, and obesity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 52 citations in OpenAlex.
- Analysis of biomarkers and metabolic pathways in patients with unstable angina based on ultra‑high‑performance liquid chromatography‑quadrupole time‑of‑flight mass spectrometry.Molecular medicine reports · 2020Trial
- Dihydrotestosterone is a predictor for mortality in males with community-acquired pneumonia: results of a 6-year follow-up study.Respiratory research · 2018Trial
- Association between Serum Testosterone and Aortic Valve Stenosis: A Prospective Cohort Study.Journal of cardiovascular development and disease · 2023Article
- Major adverse cardiovascular events associated with testosterone treatment: a pharmacovigilance study of the FAERS database.Frontiers in pharmacology · 2023Article
- Leveraging Nanomechanical Perturbations in Raman Spectro-Immunoassays to Design a Versatile Serum Biomarker Detection Platform.Small (Weinheim an der Bergstrasse, Germany) · 2022Article
- Article
- Testosterone Level Reduction Increases the 10-Year Risk of Cardiovascular Diseases: A Retrospective Cohort Study in a Taiwanese Young Male Population.Frontiers in cardiovascular medicine · 2022Article
- Plasma metabolomic profiling in subclinical atherosclerosis: the Diabetes Heart Study.Cardiovascular diabetology · 2021Article
- Testosterone and estradiol in men with acute ischemic stroke: A North Indian case control.Current journal of neurology · 2021Article
- The Effect of High-Intensity Interval Training Periods on Morning Serum Testosterone and Cortisol Levels and Physical Fitness in Men Aged 35-40 Years.Journal of clinical medicine · 2021Article
- Does androgen-deprivation therapy increase the risk of ischemic cardiovascular and cerebrovascular diseases in patients with prostate cancer? A nationwide population-based cohort study.Journal of cancer research and clinical oncology · 2021Article
- Changes in testosterone prescribing patterns after FDA warning.Translational andrology and urology · 2019Article
- Aqueous extract ofFood science and biotechnology · 2019Article
- The association between serum testosterone and insulin resistance: a longitudinal study.Endocrine connections · 2018Article
- Shift from androgen to estrogen action causes abdominal muscle fibrosis, atrophy, and inguinal hernia in a transgenic male mouse model.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Testosterone, myocardial function, and mortality.Heart failure reviews · 2018Review
- Role for Growth Regulation by Estrogen in Breast Cancer 1 (GREB1) in Hormone-Dependent Cancers.International journal of molecular sciences · 2018Review
- Serum androgens and risk of atrial fibrillation in older men: The Cardiovascular Health Study.Clinical cardiology · 2018Article
- Article
- Sex Hormones and Sex Chromosomes Cause Sex Differences in the Development of Cardiovascular Diseases.Arteriosclerosis, thrombosis, and vascular biology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
purpose of reviewThe purpose of this study is to review recent studies that examined the association of endogenous and exogenous testosterone and mortality in older men. RECENT
findingsOver the past several years, there has been a steep rise in testosterone prescriptions. The increased use of testosterone occurred in the context of several studies that reported an association between low serum testosterone and increased cardiovascular events and mortality. In contrast, recent studies have reported an association between testosterone treatment and adverse events. A testosterone treatment trial of mobility-impaired elderly men with prevalent cardiovascular disease was stopped due to increased cardiovascular events in the T-treated men and a meta-analysis reported increased cardiovascular events in T-treated men. In two recent large observational studies, testosterone treatment was associated with an increased risk for serious adverse cardiovascular events. SUMMARY: Low testosterone is associated with mortality in multiple cohort studies; however, it is unclear if this is a causal association or due to low testosterone being a biomarker of poor health. Given recent reports of adverse outcomes associated with testosterone treatment, a conservative use of testosterone is warranted in men with cardiovascular disease who may be at greater risk for adverse outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.