Trial reportPloS one2014
Reducing communication delays and improving quality of care with a tuberculosis laboratory information system in resource poor environments: a cluster randomized controlled trial.
Trial report in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01201941 (Operational Assessment of Laboratory Information System for MDR-TB in Lima, Peru), which is not on this map. Cited by 15 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Operational Assessment of Laboratory Information System for MDR-TB in Lima, Peru
Who cites it
15 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- eHealth in TB clinical management.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2022Pooled it
- Pooled it
- Routine Health Information Systems in the European Context: A Systematic Review of Systematic Reviews.International journal of environmental research and public health · 2021Pooled it
- Laboratory test ordering in inpatient hospitals: a systematic review on the effects and features of clinical decision support systems.BMC medical informatics and decision making · 2021Pooled it
- Routine Health Information System (RHIS) improvements for strengthened health system management.The Cochrane database of systematic reviews · 2020Pooled it
- Time to treatment for rifampicin-resistant tuberculosis: systematic review and meta-analysis.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2017Pooled it
- Factors Influencing Data Quality in Electronic Health Record Systems in 50 Health Facilities in Rwanda and the Role of Clinical Alerts: Cross-Sectional Observational Study.JMIR public health and surveillance · 2024Observational
- Laboratory Data Timeliness and Completeness Improves Following Implementation of an Electronic Laboratory Information System in Côte d'Ivoire: Quasi-Experimental Study on 21 Clinical Laboratories From 2014 to 2020.JMIR public health and surveillance · 2024Article
- Design and prototype of TOMO: an app for improving drug resistant TB treatment adherence.F1000Research · 2021Article
- Patients and Medical Staff Attitudes Toward the Future Inclusion of eHealth in Tuberculosis Management: Perspectives From Six Countries Evaluated using a Qualitative Framework.JMIR mHealth and uHealth · 2020Article
- Bench, bed and beyond: Communication and responsibility in decentralised tuberculosis care.Health SA = SA Gesondheid · 2019Article
- Implementing an Open Source Electronic Health Record System in Kenyan Health Care Facilities: Case Study.JMIR medical informatics · 2018Article
- Open-source LIMS in Vietnam: The path toward sustainability and host country ownership.International journal of medical informatics · 2016Article
- Mycobacterium tuberculosis: 2014 Clinical trials in review.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicaleArticle
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
backgroundLost, delayed or incorrect laboratory results are associated with delays in initiating treatment. Delays in treatment for Multi-Drug Resistant Tuberculosis (MDR-TB) can worsen patient outcomes and increase transmission. The objective of this study was to evaluate the impact of a laboratory information system in reducing delays and the time for MDR-TB patients to culture convert (stop transmitting).
methods
setting78 primary Health Centers (HCs) in Lima, Peru. Participants lived within the catchment area of participating HCs and had at least one MDR-TB risk factor. The study design was a cluster randomized controlled trial with baseline data. The intervention was the e-Chasqui web-based laboratory information system. Main outcome measures were: times to communicate a result; to start or change a patient's treatment; and for that patient to culture convert.
results1671 patients were enrolled. Intervention HCs took significantly less time to receive drug susceptibility test (DST) (median 11 vs. 17 days, Hazard Ratio 0.67 [0.62-0.72]) and culture (5 vs. 8 days, 0.68 [0.65-0.72]) results. The time to treatment was not significantly different, but patients in intervention HCs took 16 days (20%) less time to culture convert (p = 0.047).
conclusionsThe eChasqui system reduced the time to communicate results between laboratories and HCs and time to culture conversion. It is now used in over 259 HCs covering 4.1 million people. This is the first randomized controlled trial of a laboratory information system in a developing country for any disease and the only study worldwide to show clinical impact of such a system.
trial registrationClinicalTrials.gov NCT01201941.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.