ArticleScientific reports2014
Mast cell-derived serine proteinase regulates T helper 2 polarization.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Longitudinal cytokine and multi-modal health data of an extremely severe ME/CFS patient with HSD reveals insights into immunopathology, and disease severity.Frontiers in immunology · 2024Article
- TLR2 Regulates Mast Cell IL-6 and IL-13 Production DuringFrontiers in immunology · 2021Article
- Review
- Immune cell diversity contributes to the pathogenesis of myocarditis.Heart failure reviews · 2019Review
- The role of extracellular vesicles when innate meets adaptive.Seminars in immunopathology · 2018Review
- Role of Mast Cells in Regulation of T Cell Responses in Experimental and Clinical Settings.Clinical reviews in allergy & immunology · 2018Review
- A vitamin D receptor agonist converts CD4+ T cells to Foxp3+ regulatory T cells in patients with ulcerative colitis.Oncotarget · 2017Article
- Peroxisome proliferator-activated receptor γ agonist suppresses mast cell maturation and induces apoptosis.Molecular medicine reports · 2017Article
- Hair and stress: A pilot study of hair and cytokine balance alteration in healthy young women under major exam stress.PloS one · 2017Article
- Mast Cells and Irritable Bowel Syndrome: From the Bench to the Bedside.Journal of neurogastroenterology and motility · 2016Review
- Regulation of Th2 Cell Immunity by Dendritic Cells.Immune network · 2016Review
- Donor-derived exosomes induce specific regulatory T cells to suppress immune inflammation in the allograft heart.Scientific reports · 2016Article
- Flagellin modulates IgE expression in B cells to initiate food allergy in mice.American journal of translational research · 2016Article
- Tolerogenic IDO(+) Dendritic Cells Are Induced by PD-1-Expressing Mast Cells.Frontiers in immunology · 2016Article
- Therapeutic and continuative effects of human umbilical cord-derived mesenchymal stromal cells in food-allergic mice.Cell transplantationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although mast cells play a critical role in allergic reactions, the cells are also involved in the protective immunity in the body. This study aims to investigate the role of mast cells in immune regulation during aberrant T helper (Th)2 responses. In this study, an adoptive antigen-specific Th2 response model was established with mast cell-deficient mice to test the role of mast cell in the immune regulation. Cell culture was employed to test the role of mast cells in the modulation of the expression of B cell lymphoma 6 protein (Bcl-6) in Th2 cells. The results showed that after adoptive transfer with immune cells, the mast cell-deficient mice showed stronger Th2 pattern responses in the intestine than that in the mast cell-sufficient mice. Mast cell-derived mouse mast cell protease-6 increased the expression of Bcl-6 in Th2 cells. Bcl-6 inhibited the expression of GATA-3 in Th2 cells, subsequently, forkhead box P3 was increased and the Th2 cytokines were reduced in the cells; the cells thus showed the immune regulatory properties similar to regulatory T cells. We conclude that bedsides initiating immune inflammation, mast cells also contribute to the immune regulation on Th2 polarization.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.