ArticleNature communications2014
Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen.
Article in Nature communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed.
- Article
- The Genomic Basis of the Svalbard Reindeer's Adaptation to an Extreme Arctic Environment.Genome biology and evolution · 2025Article
- How genomic insights into the evolutionary history of clouded leopards inform their conservation.Science advances · 2023Article
- Embigin is a fibronectin receptor that affects sebaceous gland differentiation and metabolism.Developmental cell · 2022Article
- Article
- Identification of Copy Number Variants in a Southern Chinese Cohort of Patients with Congenital Scoliosis.Genes · 2021Article
- Roles of HIF and 2-Oxoglutarate-Dependent Dioxygenases in Controlling Gene Expression in Hypoxia.Cancers · 2021Review
- Mapping OScientific reports · 2020Article
- MYSM1 Suppresses Cellular Senescence and the Aging Process to Prolong Lifespan.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Article
- Dynamic shifts in chromatin states differentially mark the proliferative basal cells and terminally differentiated cells of the developing epidermis.Epigenetics · 2020Article
- Phosphatase Regulator NIPP1 Restrains Chemokine-Driven Skin Inflammation.The Journal of investigative dermatology · 2020Article
- Deubiquitinase MYSM1 in the Hematopoietic System and beyond: A Current Review.International journal of molecular sciences · 2020Review
- Predicting human disease mutations and identifying drug targets from mouse gene knockout phenotyping campaigns.Disease models & mechanisms · 2019Review
- Phenotypic analysis of Myo10 knockout (Myo10Scientific reports · 2019Article
- Generating mouse models for biomedical research: technological advances.Disease models & mechanisms · 2019Review
- Immunomodulatory role of Keratin 76 in oral and gastric cancer.Nature communications · 2018Article
- Article
- Whole-mount Confocal Microscopy for Adult Ear Skin: A Model System to Study Neuro-vascular Branching Morphogenesis and Immune Cell Distribution.Journal of visualized experiments : JoVE · 2018Article
- 2A-DUB/Mysm1 Regulates Epidermal Development in Part by Suppressing p53-Mediated Programs.International journal of molecular sciences · 2018Article
- Resistant and susceptible chicken lines show distinctive responses to Newcastle disease virus infection in the lung transcriptome.BMC genomics · 2017Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Permanent stop-and-shop large-scale mouse mutant resources provide an excellent platform to decipher tissue phenogenomics. Here we analyse skin from 538 knockout mouse mutants generated by the Sanger Institute Mouse Genetics Project. We optimize immunolabelling of tail epidermal wholemounts to allow systematic annotation of hair follicle, sebaceous gland and interfollicular epidermal abnormalities using ontology terms from the Mammalian Phenotype Ontology. Of the 50 mutants with an epidermal phenotype, 9 map to human genetic conditions with skin abnormalities. Some mutant genes are expressed in the skin, whereas others are not, indicating systemic effects. One phenotype is affected by diet and several are incompletely penetrant. In-depth analysis of three mutants, Krt76, Myo5a (a model of human Griscelli syndrome) and Mysm1, provides validation of the screen. Our study is the first large-scale genome-wide tissue phenotype screen from the International Knockout Mouse Consortium and provides an open access resource for the scientific community.
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