Evidence map›Paper›PMID 24721892›Full record

Trial reportClinical journal of the American Society of Nephrology : CJASN2014

Effects of frequent hemodialysis on perceived caregiver burden in the Frequent Hemodialysis Network trials.

Rita S Suri, Brett Larive, Yoshio Hall, Paul L Kimmel, Alan S Kliger, Nathan Levin, Manjula Kurella Tamura, Glenn M Chertow, Frequent Hemodialysis Network (FHN) Trial Group

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical journal of the American Society of Nephrology : CJASN, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Interventions for fatigue in people with kidney failure requiring dialysis.The Cochrane database of systematic reviews · 2023
    Pooled it
  2. Guideline
  3. Home versus in-centre haemodialysis for end-stage kidney disease.The Cochrane database of systematic reviews · 2014
    Pooled it
  4. Article
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  7. Review
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  12. Observational
  13. Article
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  15. Review
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  18. Article
  19. Behavioral stage of change and dialysis decision-making.Clinical journal of the American Society of Nephrology : CJASN · 2015
    Article
  20. Caregiver burden and hemodialysis.Clinical journal of the American Society of Nephrology : CJASN · 2014
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Rita S SuriDue to the number of contributing authors, the affiliations are provided in the Supplemental Material.
Brett Larive
Yoshio Hall
Paul L Kimmel
Alan S Kliger
Nathan Levin
Manjula Kurella Tamura
Glenn M Chertow
Frequent Hemodialysis Network (FHN) Trial Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesPatients receiving hemodialysis often perceive their caregivers are overburdened. We hypothesize that increasing hemodialysis frequency would result in higher patient perceptions of burden on their unpaid caregivers. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: In two separate trials, 245 patients were randomized to receive in-center daily hemodialysis (6 days/week) or conventional hemodialysis (3 days/week) while 87 patients were randomized to receive home nocturnal hemodialysis (6 nights/week) or home conventional hemodialysis for 12 months. Changes in overall mean scores over time in the 10-question Cousineau perceived burden scale were compared.

resultsIn total, 173 of 245 (70%) and 80 of 87 (92%) randomized patients in the Daily and Nocturnal Trials, respectively, reported having an unpaid caregiver at baseline or during follow-up. Relative to in-center conventional dialysis, the 12-month change in mean perceived burden score with in-center daily hemodialysis was -2.1 (95% confidence interval, -9.4 to +5.3; P=0.58). Relative to home conventional dialysis, the 12-month change in mean perceived burden score with home nocturnal dialysis was +6.1 (95% confidence interval, -0.8 to +13.1; P=0.08). After multiple imputation for missing data in the Nocturnal Trial, the relative difference between home nocturnal and home conventional hemodialysis was +9.4 (95% confidence interval, +0.55 to +18.3; P=0.04). In the Nocturnal Trial, changes in perceived burden were inversely correlated with adherence to dialysis treatments (Pearson r=-0.35; P=0.02).

conclusionRelative to conventional hemodialysis, in-center daily hemodialysis did not result in higher perceptions of caregiver burden. There was a trend to higher perceived caregiver burden among patients randomized to home nocturnal hemodialysis. These findings may have implications for the adoption of and adherence to frequent nocturnal hemodialysis.

Indexed as

CaregiversCost of IllnessAdultAgedAmbulatory Care FacilitiesFemaleHemodialysis, HomeHumansMaleMiddle AgedPatient CompliancePerceptionRenal DialysisRenal Insufficiency, ChronicSurveys and Questionnairesdaily hemodialysisoutcomesrandomized controlled trials

Identifiers

PMID24721892
PMCPMC4011443

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.