ArticleReproductive biology and endocrinology : RB&E2014
Maternal obesity and diabetes may cause DNA methylation alteration in the spermatozoa of offspring in mice.
Article in Reproductive biology and endocrinology : RB&E, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 63 citations in OpenAlex.
- Effects of obesity on DNA methylation and DNA methyltransferases in the reproductive system.Histochemistry and cell biology · 2026Review
- Methods for Investigating the Sperm Epigenome.Advances in experimental medicine and biology · 2026Review
- Sperm epigenetics and sperm RNAs as drivers of male infertility: truth or myth?Molecular and cellular biochemistry · 2025Review
- Maternal Obesity Induces the Meiotic Defects and Epigenetic Alterations During Fetal Oocyte Development.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Review
- A comprehensive approach to modeling maternal immune activation in rodents.Frontiers in neuroscience · 2022Review
- Looking at the Future Through the Mother's Womb: Gestational Diabetes and Offspring Fertility.Endocrinology · 2021Review
- Article
- Epigenetics of Male Infertility: The Role of DNA Methylation.Frontiers in cell and developmental biology · 2021Review
- Maternal Obesity Programs Offspring Development and Resveratrol Potentially Reprograms the Effects of Maternal Obesity.International journal of environmental research and public health · 2020Review
- The Roles of H19 in Regulating Inflammation and Aging.Frontiers in immunology · 2020Review
- Impacts of obesity, maternal obesity and nicotinamide mononucleotide supplementation on sperm quality in mice.Reproduction (Cambridge, England) · 2019Article
- In Utero and Postnatal Exposure to High Fat, High Sucrose Diet Suppressed Testis Apoptosis and Reduced Sperm Count.Scientific reports · 2018Article
- Long non-coding RNA H19 induces hippocampal neuronal apoptosisOncotarget · 2017Article
- Epigenetic signatures of gestational diabetes mellitus on cord blood methylation.Clinical epigenetics · 2017Article
- Maternal medical conditions during pregnancy and gross motor development up to age 24 months in the Upstate KIDS study.Developmental medicine and child neurology · 2016Article
- Obesity-related DNA methylation at imprinted genes in human sperm: Results from the TIEGER study.Clinical epigenetics · 2016Article
- Environmental Susceptibility of the Sperm Epigenome During Windows of Male Germ Cell Development.Current environmental health reports · 2015Article
- Epigenetic Alterations in Human Liver From Subjects With Type 2 Diabetes in Parallel With Reduced Folate Levels.The Journal of clinical endocrinology and metabolism · 2015Article
- Select Prenatal Environmental Exposures and Subsequent Alterations of Gene-Specific and Repetitive Element DNA Methylation in Fetal Tissues.Current environmental health reports · 2015Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe adverse effects on offspring of diabetic and/or obese mothers can be passed to the next generation. However, the mechanisms behind this are still unclear. Epigenetics may play a key role during this process.
methodsTo confirm the hypothesis, we investigated the DNA methylation of several imprinted genes in spermatozoa of offspring from diabetic and/or obese mothers utilizing streptozotocin (STZ)- and high-fat-diet (HFD)-induced mouse models.
resultsWe found that the DNA methylation of Peg3 was significantly increased in spermatozoa of offspring of obese mothers compared to that in spermatozoa of offspring of normal mothers. The DNA methylation of H19 was significantly higher in spermatozoa of offspring of diabetic mothers than that in spermatozoa of offspring of non-diabetic mothers.
conclusionsThese results indicate that pre-gestational diabetes and/or obesity can alter DNA methylation in offspring spermatozoa.
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