ArticleWorld journal of surgical oncology2014
The importance of biopsy in clinically diagnosed metastatic lesions in patients with breast cancer.
Article in World journal of surgical oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Article
- Solitary gastric metastasis from invasive lobular breast cancer misdiagnosed as gastritis: a case description.Quantitative imaging in medicine and surgery · 2024Article
- Differentiating Primary and Recurrent Lesions in Patients with a History of Breast Cancer: A Comprehensive Review.Galen medical journal · 2024Article
- Article
- Article
- Association of Biomarker Discrepancy and Treatment Decision, Disease Outcome in Recurrent/Metastatic Breast Cancer Patients.Frontiers in oncology · 2021Article
- A Rare Metastatic Site of Invasive Lobular Breast Carcinoma: A Case Report.Case reports in surgery · 2021Article
- Review
- ESR1-promoter-methylation status in primary breast cancer and its corresponding metastases.Clinical & experimental metastasis · 2018Article
- Clinical Potential of Estrogen and Progesterone Receptor Imaging.PET clinics · 2018Review
- Gastric metastasis from invasive lobular breast cancer, mimicking primary gastric cancer: A case report.Medicine · 2018Article
- Article
- Primary or metastatic hepatic carcinoma? A breast cancer patient after adjuvant chemotherapy and radiotherapy postoperatively with intrahepatic cholangiocarcinoma and review of the literature.World journal of surgical oncology · 2016Review
- Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundReceptor status discordance, such as estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) status between primary breast cancer and metastatic lesions has been reported. The aim of this study was to evaluate the biopsy of clinically diagnosed metastatic lesions and to determine the changes in hormonal receptor and HER2 status of the metastatic lesions.
methodsSixty-three patients with clinically diagnosed metastatic breast cancer underwent an excisional biopsy or core needle aspiration guided by computed tomography/ultrasound. ER, PR and HER2 were assessed by immunohistochemistry (IHC).
resultsA total of 48 metastases (76.2%) and nine second primary malignancies (14.3%, seven primary lung cancers and two primary pancreatic cancers) were found. The discrepancies between ER, PR and HER2 status between the primary breast cancer and metastatic lesions were 14.6%, 16.7% and 8.3%, respectively. Six lesions (9.5%) were proved benign upon biopsy.
conclusionsThe biopsy of clinically suspicious metastatic lesions could histologically confirm the diagnosis of metastasis, evaluate discrepancies between ER, PR and HER2 status and exclude secondary malignancy, which might change the therapeutic strategy for breast cancer patients.
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