ArticleDevelopmental biology2014
Distinct requirements for beta-catenin in pancreatic epithelial growth and patterning.
Article in Developmental biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- RSPO1, a potent inducer of pancreatic β cell neogenesis.Cell reports. Medicine · 2025Article
- LINC MIR503HG Controls SC-β Cell Differentiation and Insulin Production by Targeting CDH1 and HES1.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- NEUROD1 reinforces endocrine cell fate acquisition in pancreatic development.Nature communications · 2023Article
- Review
- Wnt4 is heterogeneously activated in maturing β-cells to control calcium signaling, metabolism and function.Nature communications · 2022Article
- Molecular signaling in pancreatic ductal metaplasia: emerging biomarkers for detection and intervention of early pancreatic cancer.Cellular oncology (Dordrecht, Netherlands) · 2022Review
- SOX9+/PTF1A+ Cells Define the Tip Progenitor Cells of the Human Fetal Pancreas of the Second Trimester.Stem cells translational medicine · 2019Article
- Defining multistep cell fate decision pathways during pancreatic development at single-cell resolution.The EMBO journal · 2019Article
- Chemically defined conditions for long-term maintenance of pancreatic progenitors derived from human induced pluripotent stem cells.Scientific reports · 2019Article
- Pancreatic Exocrine Tissue Architecture and Integrity are Maintained by E-cadherin During Postnatal Development.Scientific reports · 2018Article
- Understanding human fetal pancreas development using subpopulation sorting, RNA sequencing and single-cell profiling.Development (Cambridge, England) · 2018Article
- The role of adherens junction proteins in the regulation of insulin secretion.Bioscience reports · 2018Review
- Effect of Wnt Signaling on the Differentiation of IsletBioMed research international · 2017Article
- Loss of Pancreas upon Activated Wnt Signaling Is Concomitant with Emergence of Gastrointestinal Identity.PloS one · 2016Article
- Notch Signaling in Pancreatic Development.International journal of molecular sciences · 2015Review
- Neural cells play an inhibitory role in pancreatic differentiation of pluripotent stem cells.Genes to cells : devoted to molecular & cellular mechanisms · 2015Article
- Mesenchymal Hox6 function is required for mouse pancreatic endocrine cell differentiation.Development (Cambridge, England) · 2015Article
- Progenitor potential of nkx6.1-expressing cells throughout zebrafish life and during beta cell regeneration.BMC biology · 2015Article
- Tshz1 Regulates Pancreatic β-Cell Maturation.Diabetes · 2015Article
- Establishment of a porcine pancreatic stem cell line using T-REx(™) system-inducible Wnt3a expression.Cell proliferation · 2015Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Pancreatic exocrine and endocrine lineages arise from multipotent pancreatic progenitor cells (MPCs). Exploiting the mechanisms that govern expansion and differentiation of these cells could enhance efforts to generate β-cells from stem cells. Although our prior work indicates that the canonical Wnt signaling component β-catenin is required qualitatively for exocrine acinar but not endocrine development, precisely how this requirement plays out at the level of MPCs and their lineage-restricted progeny is unknown. In addition, the contribution of β-catenin function to β-cell development remains controversial. To resolve the potential roles of β-catenin in development of MPCs and β-cells, we generated pancreas- and pre-endocrine-specific β-catenin knockout mice. Pancreas-specific loss of β-catenin produced not only a dramatic reduction in acinar cell numbers, but also a significant reduction in β-cell mass. The loss of β-cells is due not to a defect in the differentiation of endocrine precursors, but instead correlates with an early and specific loss of MPCs. In turn, this reflects a novel role for β-catenin in maintaining proximal-distal patterning of the early epithelium, such that distal MPCs resort to a proximal, endocrine-competent "trunk" fate when β-catenin is deleted. Moreover, β-catenin maintains proximal-distal patterning, in part, by inhibiting Notch signaling. Subsequently, β-catenin is required for proliferation of both distal and proximal cells, driving overall organ growth. In distinguishing two distinct roles for β-catenin along the route of β-cell development, we suggest that temporally appropriate positive and negative manipulation of this molecule could enhance expansion and differentiation of stem cell-derived MPCs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.