ArticleProteome science2014
Host defence related responses in bovine milk during an experimentally induced Streptococcus uberis infection.
Article in Proteome science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Inflammation-Associated Changes in Bioactive Proteins and Peptides of Bovine Milk: Evidence from Mastitis, Lameness, and Metabolic Disorders-A Review.Molecules (Basel, Switzerland) · 2026Review
- Distinguishing Natural Infections of the Bovine Mammary Gland byAnimals : an open access journal from MDPI · 2023Article
- Immunological and Oxidative Biomarkers in Bovine Serum from Healthy, Clinical, and Sub-Clinical Mastitis Caused byAnimals : an open access journal from MDPI · 2023Article
- Proteomic 2D-DIGE Analysis of Milk Whey from Dairy Cows withMicroorganisms · 2020Article
- In Depth Analysis of the Contribution of Specific Glycoproteins to the Overall Bovine Whey N-Linked Glycoprofile.Journal of agricultural and food chemistry · 2020Article
- The secretome from bovine mammosphere-derived cells (MDC) promotes angiogenesis, epithelial cell migration, and contains factors associated with defense and immunity.Scientific reports · 2018Article
- Immunomodulation of Host Chitinase 3-Like 1 During a Mammary PathogenicFrontiers in immunology · 2018Article
- Identification of Host Defense-Related Proteins Using Label-Free Quantitative Proteomic Analysis of Milk Whey from Cows with Staphylococcus aureus Subclinical Mastitis.International journal of molecular sciences · 2017Article
- Exploration of the bovine colostrum proteome and effects of heat treatment time on colostrum protein profile.Journal of dairy science · 2017Article
- Article
- Abundance of RNase4 and RNase5 mRNA and protein in host defence related tissues and secretions in cattle.Biochemistry and biophysics reports · 2016Article
- Mastitomics, the integrated omics of bovine milk in an experimental model of Streptococcus uberis mastitis: 2. Label-free relative quantitative proteomics.Molecular bioSystems · 2016Article
- Keratin and S100 calcium-binding proteins are major constituents of the bovine teat canal lining.Veterinary research · 2015Article
- Extracellular milieu grossly alters pathogen-specific immune response of mammary epithelial cells.BMC veterinary research · 2015Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMilk contains a range of proteins of moderate or low abundance that contribute to host defence. Characterisation of these proteins, the extent to which their abundance is regulated by pathogenic stimuli, and the variability of their response between and within individual animals would facilitate a better understanding of the molecular basis for this important function of milk.
resultsWe have characterised the host defence proteins in bovine milk and their responses to intra-mammary infection by a common Gram positive mastitis pathogen, Streptococcus uberis, using a combination of 2D gel electrophoresis and GeLC mass spectrometry. In total, 68 host defence-associated proteins were identified, 18 of which have a direct antimicrobial function, 23 of which have a pathogen-recognition function, and 27 of which have a role in modulating inflammatory or immune signalling. The responsiveness of seven proteins was quantified by western blotting; validating the proteomic analyses, quantifying the within- and between animal variability of the responses, and demonstrating the complexity and specificity of the responses to this pathogen.
conclusionsThese data provide a foundation for understanding the role of milk in host-microbe interaction. Furthermore they provide candidate biomarkers for mastitis diagnosis, and will inform efforts to develop dairy products with improved health-promoting properties.
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