Evidence map›Paper›PMID 24721613›Full record

ReviewActa biomaterialia2014

Implant osseointegration and the role of microroughness and nanostructures: lessons for spine implants.

Rolando A Gittens, Rene Olivares-Navarrete, Zvi Schwartz, Barbara D Boyan

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Acta biomaterialia, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers.

0numbers the graph read from it
0cells of the map it votes in
116citing papers in PubMed
16.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

116 citing papers in PubMed, 427 citations in OpenAlex.

  1. Clinical and radiological results of TLIF surgery with titanium-coated PEEK or uncoated PEEK cages: a prospective single-centre randomised study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2024
    Trial
  2. PLIF surgery with titanium-coated PEEK or uncoated PEEK cages: a prospective randomised clinical and radiological study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2021
    Trial
  3. Article
  4. Review
  5. Aetiology of early implant failure: a scoping review.Clinical oral investigations · 2026
    Article
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56 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Rolando A GittensSchool of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, GA, USA; Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA; Center for Biodiversity and Drug Discovery, Institute for Scientific Research and High Technology Services (INDICASAT-AIP), Panama, Panama.
Rene Olivares-NavarreteDepartment of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA, USA.
Zvi SchwartzInstitute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA; Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA, USA.
Barbara D BoyanSchool of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, GA, USA; Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA; Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA, USA; Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Georgia Institute of Technology, Atlanta, GA, USA. Electronic address: bboyan@vcu.edu.
Virginia Commonwealth University · USGeorgia Institute of Technology · US

Funding

Mechanisms of Cell/Surface InteractionR01AR052102 · NIAMS · VIRGINIA COMMONWEALTH UNIVERSITY · PI BOYAN, BARBARA D. · 2006 to 2015
$3.3M
NIAMS NIH HHS AR052102NIAMS NIH HHS R01 AR052102
6 · The paper itself

Abstract

The use of spinal implants for spine fusion has been steadily increasing to avoid the risks of complications and donor site morbidity involved when using autologous bone. A variety of fusion cages are clinically available, with different shapes and chemical compositions. However, detailed information about their surface properties and the effects of such properties on osteogenesis is lacking in the literature. Here we evaluate the role of surface properties for spinal implant applications, covering some of the key biological processes that occur around an implant and focusing on the role of surface properties, specifically the surface structure, on osseointegration, drawing examples from other implantology fields when required. Our findings revealed that surface properties such as microroughness and nanostructures can directly affect early cell behavior and long-term osseointegration. Microroughness has been well established in the literature to have a beneficial effect on osseointegration of implants. In the case of the role of nanostructures, the number of reports is increasing and most studies reveal a positive effect from the nanostructures alone and a synergistic effect when combined with microrough surfaces. Long-term clinical results are nevertheless necessary to establish the full implications of surface nanomodifications.

Indexed as

Prostheses and ImplantsAnimalsBiocompatible MaterialsEquipment Failure AnalysisHumansNanostructuresOsseointegrationProsthesis DesignSpinal FusionSpineSurface PropertiesBiocompatible MaterialsBoneNanostructuresSpine fusionTitanium surface propertiesTopography roughness

Identifiers

PMID24721613
PMCPMC4103432
OpenAlexW2084960929

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.