ArticleCell host & microbe2014
Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
Article in Cell host & microbe, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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43 citing papers in PubMed, 111 citations in OpenAlex.
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- The genetic orchestra of salicylic acid in plant resilience to climate change induced abiotic stress: critical review.Stress biology · 2024Review
- Comprehensive identification of maize ZmE2F transcription factors and the positive role of ZmE2F6 in response to drought stress.BMC genomics · 2024Article
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- Phytophthora sojae effector PsAvh113 associates with the soybean transcription factor GmDPB to inhibit catalase-mediated immunity.Plant biotechnology journal · 2023Article
- Emerging Roles of Salicylic Acid in Plant Saline Stress Tolerance.International journal of molecular sciences · 2023Review
- Oxicam-type nonsteroidal anti-inflammatory drugs enhancePlant biotechnology (Tokyo, Japan) · 2022Article
- Natural variation in the transcription factor REPLUMLESS contributes to both disease resistance and plant growth in Arabidopsis.Plant communications · 2022Article
- Ethylene-responsive factor ERF114 mediates fungal pathogen effector PevD1-induced disease resistance in Arabidopsis thaliana.Molecular plant pathology · 2022Article
- Metabolic Profile Discriminates and PredictsMetabolites · 2021Article
- GmBTB/POZ promotes the ubiquitination and degradation of LHP1 to regulate the response of soybean to Phytophthora sojae.Communications biology · 2021Article
- Understanding the molecular mechanisms of trade-offs between plant growth and immunity.Science China. Life sciences · 2021Review
- CRISPR/Cas9 Targeted Editing of Genes Associated With Fungal Susceptibility inFrontiers in plant science · 2021Article
- Molecular Analysis of the E2F/DP Gene Family ofFrontiers in plant science · 2021Article
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6 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
In plants, the activation of immunity is often inversely correlated with growth. Mechanisms that control plant growth in the context of pathogen challenge and immunity are unclear. Investigating Arabidopsis infection with the powdery mildew fungus, we find that the Arabidopsis atypical E2F DEL1, a transcriptional repressor known to promote cell proliferation, represses accumulation of the hormone salicylic acid (SA), an established regulator of plant immunity. DEL1-deficient plants are more resistant to pathogens and slightly smaller than wild-type. The resistance and size phenotypes of DEL1-deficient plants are due to the induction of SA and activation of immunity in the absence of pathogen challenge. Moreover, Enhanced Disease Susceptibility 5 (EDS5), a SA transporter required for elevated SA and immunity, is a direct repressed target of DEL1. Together, these findings indicate that DEL1 control of SA levels contributes to regulating the balance between growth and immunity in developing leaves.
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