ReviewCurrent opinion in structural biology2014
Increasing occurrences and functional roles for high energy purine-pyrimidine base-pairs in nucleic acids.
Review in Current opinion in structural biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- A chemoproteomic atlas of the human purine interactome for regioselective ligand discovery.Nature communications · 2026Article
- Application of Synchrotron Radiation Circular Dichroism for Structural Analysis of RNAs.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Article
- Recognition of Noncanonical RNA Base Pairs Using Triplex-Forming Peptide Nucleic Acids.ACS chemical biology · 2025Article
- Slow Rotational Dynamics of Cytosine NHBiochemistry · 2022Article
- U5 snRNA Interactions With Exons Ensure Splicing Precision.Frontiers in genetics · 2021Article
- RNA-mediated gene fusion in mammalian cells.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- m(1)A and m(1)G disrupt A-RNA structure through the intrinsic instability of Hoogsteen base pairs.Nature structural & molecular biology · 2016Article
- Tautomers of a Fluorescent G Surrogate and Their Distinct Photophysics Provide Additional Information Channels.Angewandte Chemie (International ed. in English) · 2016Article
- Structural basis for molecular discrimination by a 3',3'-cGAMP sensing riboswitch.Cell reports · 2015Article
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Authors and funding
2 authors.
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Abstract
There are a growing number of studies reporting the observation of purine-pyrimidine base-pairs that are seldom observed in unmodified nucleic acids because they entail the loss of energetically favorable interactions or require energetically costly base ionization or tautomerization. These high energy purine-pyrimidine base-pairs include G•C(+) and A•T Hoogsteen base-pairs, which entail ∼180° rotation of the purine base in a Watson-Crick base-pair, protonation of cytosine N3, and constriction of the C1'-C1' distance by ∼2.5Å. Other high energy pure-pyrimidine base-pairs include G•T, G•U, and A•C mispairs that adopt Watson-Crick like geometry through either base ionization or tautomerization. Although difficult to detect and characterize using biophysical methods, high energy purine-pyrimidine base-pairs appear to be more common than once thought. They further expand the structural and functional diversity of canonical and non-canonical nucleic acid base-pairs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.