Evidence map›Paper›PMID 24721449›Full record

ReviewCurrent opinion in structural biology2014

Template-based structure modeling of protein-protein interactions.

Andras Szilagyi, Yang Zhang

Abstract readReview
In one paragraph

Review in Current opinion in structural biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Flexible protein-protein docking with a multitrack iterative transformer.Protein science : a publication of the Protein Society · 2024
    Article
  6. Article
  7. Review
  8. Characterization of epitranscriptome reader proteins experimentally andComputational and structural biotechnology journal · 2023
    Review
  9. Dockground resource for protein recognition studies.Protein science : a publication of the Protein Society · 2022
    Article
  10. Article
  11. Article
  12. Protein-Protein Interaction Prediction for Targeted Protein Degradation.International journal of molecular sciences · 2022
    Article
  13. Article
  14. Protein-protein interaction prediction with deep learning: A comprehensive review.Computational and structural biotechnology journal · 2022
    Review
  15. Biomolecular Topology: Modelling and Analysis.Acta mathematica Sinica, English series · 2022
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Andras SzilagyiInstitute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Karolina út 29, Budapest 1113, Hungary.
Yang ZhangDepartment of Computational Medicine & Bioinformatics, The University of Michigan, 100 Washtenaw Avenue, 2035B, Ann Arbor, MI 48109-2218, USA; Department of Biological Chemistry, The University of Michigan, 100 Washtenaw Avenue, 2035B, Ann Arbor, MI 48109-2218, USA. Electronic address: zhng@umich.edu.

Funding

I-TASSER based atomic-level protein structure predictionR01GM083107 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZHANG, YANG · 2008 to 2019
$3.5M
Atomic-level, large-scale structure prediction of G protein-coupled receptorsR01GM084222 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZHANG, YANG · 2009 to 2012
$1.3M
NIGMS NIH HHS GM083107NIGMS NIH HHS GM084222NIGMS NIH HHS R01 GM083107NIGMS NIH HHS R01 GM084222
6 · The paper itself

Abstract

The structure of protein-protein complexes can be constructed by using the known structure of other protein complexes as a template. The complex structure templates are generally detected either by homology-based sequence alignments or, given the structure of monomer components, by structure-based comparisons. Critical improvements have been made in recent years by utilizing interface recognition and by recombining monomer and complex template libraries. Encouraging progress has also been witnessed in genome-wide applications of template-based modeling, with modeling accuracy comparable to high-throughput experimental data. Nevertheless, bottlenecks exist due to the incompleteness of the protein-protein complex structure library and the lack of methods for distant homologous template identification and full-length complex structure refinement.

Indexed as

Amino Acid SequenceAnimalsDatabases, ProteinHumansMolecular Docking SimulationMolecular Sequence DataProtein ConformationProtein Interaction MappingProteinsProteins

Identifiers

PMID24721449
PMCPMC3984454

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.