Evidence map›Paper›PMID 24721190›Full record

Observational studyAtherosclerosis2014

Mediterranean diet and carotid atherosclerosis in the Northern Manhattan Study.

Hannah Gardener, Clinton B Wright, Digna Cabral, Nikolaos Scarmeas, Yian Gu, Ken Cheung, Mitchell S V Elkind, Ralph L Sacco, Tatjana Rundek

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Atherosclerosis, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
5.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 64 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Mediterranean Diet and Its Association with Cardiovascular Disease Risk Factors: A Scoping Review.International journal of environmental research and public health · 2022
    Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Observational
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Hannah GardenerDepartment of Neurology, Miller School of Medicine, University of Miami, Miami, FL, USA. Electronic address: hgardener@med.miami.edu.
Clinton B WrightDepartment of Neurology, Miller School of Medicine, University of Miami, Miami, FL, USA.
Digna CabralDepartment of Neurology, Miller School of Medicine, University of Miami, Miami, FL, USA.
Nikolaos ScarmeasDepartment of Neurology, Sergievsky Center, Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, NY, USA; Department of Social Medicine, Psychiatry, and Neurology, National and Kapodistrian University of Athens, Athens, Greece.
Yian GuDepartment of Neurology, Sergievsky Center, Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, NY, USA.
Ken CheungDepartment of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY, USA.
Mitchell S V ElkindDepartment of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA.
Ralph L SaccoDepartment of Neurology, Miller School of Medicine, University of Miami, Miami, FL, USA.
Tatjana RundekDepartment of Neurology, Miller School of Medicine, University of Miami, Miami, FL, USA.
University of Miami · USColumbia University · USColumbia University Irving Medical Center · USNational and Kapodistrian University of Athens · GR

Funding

ZOLEDRONIC ACID IN PROSTATE CANCERM01RR000645 · NCRR · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI COLTEN, HARVEY R · 1985 to 2006
$27.0M
STROKE INCIDENCE AND RISK FACTORS IN A TRI-ETHNIC REGIONR01NS029993 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ELKIND, MITCHELL S, SACCO, RALPH L. · 1993 to 2019
$19.2M
Stroke Incidence and Risk Factors in a Tri-Ethnic RegionR37NS029993 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ELKIND, MITCHELL S, SACCO, RALPH L. · 2008 to 2014
$12.1M
NCRR NIH HHS M01 RR000645NINDS NIH HHS R01 NS029993NINDS NIH HHS R37 NS029993NINDS NIH HHS R37 NS 29993
6 · The paper itself

Abstract

objectiveAdherence to a Mediterranean-style diet (MeDi) may protect against clinical vascular events by reducing atherosclerosis, but data is limited. This is the first observational study of the association between MeDi adherence and carotid plaque thickness and area.

methodsThe study included 1374 participants of the population-based Northern Manhattan Study with diet assessed and carotid intima-media thickness (cIMT) and plaque measured using B-mode ultrasound (mean age 66 ± 9 years, 60% female, 60% Hispanic, 18% White, 19% Black). A MeDi adherence score (range = 0-9, 9 representing maximal adherence) was examined continuously and in quintiles (3/4/5/6-9 vs. 0-2).

resultsMean cIMT = 0.9 ± 0.1 mm and 57% had plaque (median plaque thickness = 1.5 mm, 75th percentile = 2.2; median plaque area = 4.2 mm(2), 75th percentile = 15.8). There was no association between MeDi and cIMT or plaque presence. MeDi adherence was inversely associated with the 75th percentile of plaque thickness and median of plaque area in quantile regression analyses. These associations persisted after controlling for demographics, smoking, physical activity, and total energy consumption (effect of a 1-point increase in MeDi score on the 75th percentile of plaque thickness = -0.049 mm, p = 0.03; median of plaque area = -0.371 mm(2), p = 0.03), and when additionally controlling for vascular disease biomarkers, medication use, BMI, and previous cardiac disease. The protective associations appeared strongest for those with a MeDi score of 5 (4th quintile) vs. 0-2 (bottom quintile). Differential effects of a MeDi on plaque thickness and area across race/ethnic groups was suggested.

conclusionsModerate and strict adherence to a MeDi may protect against a higher burden of carotid atherosclerotic plaque, which may mediate the protection against clinical vascular events. Efforts to improve adherence to a MeDi are critical to reducing the burden of atherosclerotic disease.

Indexed as

Diet, MediterraneanPatient ComplianceAgedCarotid ArteriesCarotid Artery DiseasesCarotid Intima-Media ThicknessFemaleHumansMaleMiddle AgedNew York CityPlaque, AtheroscleroticPredictive Value of TestsProtective FactorsRisk FactorsSeverity of Illness IndexCarotid atherosclerosisIntima-media thicknessMediterranean dietPlaque

Identifiers

PMID24721190
PMCPMC4370624
OpenAlexW2152727153

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.