ArticleJournal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research2014
The altered tight junctions: an important gateway of bacterial translocation in cachexia patients with advanced gastric cancer.
Article in Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
- IgG positive food elimination diet altered gut microbiota, decreased zonulin in migraine adults: a pilot dietary intervention trial.Frontiers in nutrition · 2026Trial
- The gut microbiota of hepato-pancreatico-biliary and gastric cancer patients is altered in composition and functionality.Irish journal of medical science · 2026Article
- Modulating the Gut-Muscle Axis: Increasing SCFA-Producing Gut Microbiota Commensals and Decreasing Endotoxin Production to Mitigate Cancer Cachexia.Microorganisms · 2025Review
- The gut microbiome and dietary fibres: implications in obesity, cardiometabolic diseases and cancer.Nature reviews. Microbiology · 2025Review
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- Normothermic Preservation of the Intestinal Allograft.Gastroenterology clinics of North America · 2024Review
- Treatment of Cachexia in Gastric Cancer: Exploring the Use of Anti-Inflammatory Natural Products and Their Derivatives.Nutrients · 2024Review
- Diagnosis and outcomes of cachexia in Asia: Working Consensus Report from the Asian Working Group for Cachexia.Journal of cachexia, sarcopenia and muscle · 2023Review
- Dose- and Segment-Dependent Disturbance of Rat Gut by Ionizing Radiation: Impact of Tight Junction Proteins.International journal of molecular sciences · 2023Article
- From Mouth to Muscle: Exploring the Potential Relationship between the Oral Microbiome and Cancer-Related Cachexia.Microorganisms · 2022Review
- Review
- Advanced age exacerbates intestinal epithelial permeability after burn injury in mice.Experimental gerontology · 2022Article
- Gut-muscle crosstalk. A perspective on influence of microbes on muscle function.Frontiers in medicine · 2022Article
- Cancer cachexia as a multiorgan failure: Reconstruction of the crime scene.Frontiers in cell and developmental biology · 2022Review
- Article
- Yogurt Produced by Novel Natural Starter Cultures Improves Gut Epithelial Barrier In Vitro.Microorganisms · 2020Article
- The Microbiota and Cancer Cachexia.International journal of molecular sciences · 2019Review
- Autophagy Strengthens Intestinal Mucosal Barrier by Attenuating Oxidative Stress in Severe Acute Pancreatitis.Digestive diseases and sciences · 2018Article
- Role of pregnane X-receptor in regulating bacterial translocation in chronic liver diseases.World journal of hepatology · 2017Review
- Revisiting the role ofGut microbesArticle
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledTight junctions (TJs) are the structural basis for the intestinal epithelium barrier. Increased intestinal permeability caused by variations in TJ proteins may result in bacterial translocation (BT). There is increasing evidence that BT might contribute to the occurrence and development of cancer cachexia, but the details are not known. Aims, we undertook further investigations into the pathway of BT in cancer cachexia.
resultsBT-positive patients had a higher level of claudins-2 (CL-2, P=0.035) and a lower level of occludin (P=0.038) and Zonula occluden-1 (P=0.01) than BT-negative patients. Moreover, the levels of IL-6, TNF-α, and IFN-γ in BT-positive cachexia patients were higher compared with BT-negative cachexia patients (P<0.001, P=0.01, P<0.001) and BT-positive noncachexia patients (P<0.001, P=0.025, P<0.001). In the BT-positive cachexia patients, the local concentration of IL-6, TNF-α, and IFN-γ, in the middle colic vein, was higher than in the peripheral venous (P=0.04, P=0.03, P=0.038). In addition, endotoxin was detected within the small intestinal wall, and the concentration of endotoxin decreased from the mucosal side to the serosal side gradually in BT-positive patients. This study suggests that the altered TJs could be an important gateway of BT in gastric cancer cachexia and local cytokines could play a more important role than systemic cytokines in the process.
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