ArticleNeurogastroenterology and motility2014
Diminished vagal tone is a predictive biomarker of necrotizing enterocolitis-risk in preterm infants.
Article in Neurogastroenterology and motility, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Heart rate variability and inflammatory bowel disease in humans: A systematic review and meta-analysis.Medicine · 2020Pooled it
- The protective effect of cutaneous vagus nerve stimulation from necrotizing enterocolitis (NEC) in neonatal rats.Pediatric research · 2026Article
- From standard to individualized diazoxide therapy in congenital hyperinsulinism: a narrative review.Frontiers in pharmacology · 2026Review
- Preoperative autonomic failure in neonates with critical congenital heart disease.Early human development · 2025Article
- Heart rate variability reflects endoscopic activity and systemic inflammation in patients with Crohn's disease.Frontiers in medicine · 2025Article
- Heart rate variability: a multidimensional perspective from physiological marker to brain-heart axis disorders prediction.Frontiers in cardiovascular medicine · 2025Review
- Noninvasive Tools to Predict Necrotizing Enterocolitis in Infants with Congenital Heart Diseases: A Narrative Review.Children (Basel, Switzerland) · 2024Review
- Prediction of outcome of hypoxic-ischemic encephalopathy in newborns undergoing therapeutic hypothermia using heart rate variability.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Transforming neonatal care with artificial intelligence: challenges, ethical consideration, and opportunities.Journal of perinatology : official journal of the California Perinatal Association · 2024Review
- Understanding necrotizing enterocolitis endotypes and acquired intestinal injury phenotypes from a historical and artificial intelligence perspective.Frontiers in pediatrics · 2024Review
- State of the art review on machine learning and artificial intelligence in the study of neonatal necrotizing enterocolitis.Frontiers in pediatrics · 2023Review
- Article
- Splanchnic oxygen saturation during reoxygenation with 21% or 100% OPediatric research · 2022Article
- In infants with congenital heart disease autonomic dysfunction is associated with pre-operative brain injury.Pediatric research · 2022Article
- Structural and functional connections between the autonomic nervous system, hypothalamic-pituitary-adrenal axis, and the immune system: a context and time dependent stress response network.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Review
- Biomarkers of gut injury in neonates - where are we in predicting necrotising enterocolitis?Frontiers in pediatrics · 2022Review
- Autonomic measures identify stress, pain, and instability associated with retinopathy of prematurity ophthalmologic examinations.Frontiers in pain research (Lausanne, Switzerland) · 2022Article
- Vital signs as physiomarkers of neonatal sepsis.Pediatric research · 2022Review
- Neonatal heart rate variability: a contemporary scoping review of analysis methods and clinical applications.BMJ open · 2021Article
- Necrotizing Enterocolitis in Neonates With Hyperinsulinemic Hypoglycemia Treated With Diazoxide.Pediatrics · 2021Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundNecrotizing enterocolitis (NEC) is an acute neonatal inflammatory disease which may lead to intestinal necrosis, multisystem failure, and death. Currently, NEC is diagnosed by a combination of laboratory and radiographic tests conducted a posteriori i.e., when NEC is already clinically significant. Given the acute onset and rapid progression of NEC, a non-invasive biomarker that allows early detection of patients at risk is required as a matter of urgency. We evaluated whether the high frequency (HF) component of heart rate variability (HRV), a measure of vagal efferent tonic cholinergic activity may be used as a predictive biomarker for NEC-risk before the onset of clinical disease.
methodsIn this prospective study, stable preterm (gestational age 28-35 weeks) infants had HRV power spectra analyzed from surface electrocardiogram waveforms taken at rest on day 5-8 of life. We used regression modeling to determine the utility of HF-HRV in predicting NEC. KEY
resultsHF-HRV power was 21.5 ± 2.7 and 3.9 ± 0.81 ms(2) in infants that remained healthy and those that later developed stage 2+ NEC, respectively (p < 0.001). Nine of 70 enrolled infants developed NEC. The ROC discriminated a HF-HRV value of 4.68 ms(2) predictive for developing NEC with a sensitivity and specificity of 89% and 87%, and positive and negative predictive value of 50% and 98%, respectively. With predictive regression modeling, the risk (odds ratio) of developing NEC was 10 per every one SD decrease in HF-HRV. CONCLUSIONS & INFERENCES: Our preliminary data indicate that HF-HRV may serve as a potential, non-invasive predictive biomarker of NEC-risk in NICU infants.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.