ReviewCurrent cardiology reviews2014
Cardioprotection acquired through exercise: the role of ischemic preconditioning.
Review in Current cardiology reviews, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- Ischemia-Reperfusion Intervention: From Enhancements in Exercise Performance to Accelerated Performance Recovery-A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2020Pooled it
- Effect of Exercise Intervention on Cardiac Function in Type 2 Diabetes Mellitus: A Systematic Review.Sports medicine (Auckland, N.Z.) · 2019Pooled it
- The effects of ischemic preconditioning and placebo maneuvers are similar during arm-cranking performance in upper-body trained athletes.European journal of applied physiology · 2026Trial
- Trial
- Ischemic preconditioning reduces hemodynamic response during metaboreflex activation.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Trial
- High-intensity interval training improves mitochondrial function and attenuates cardiomyocytes damage in ischemia-reperfusion.International journal of cardiology. Heart & vasculature · 2025Review
- Molecular Mediators of the Cardiac Benefits of Exercise.Circulation research · 2025Review
- Potential Short- and Long-Term Physiological Effects of Ischemic Preconditioning as an Ergogenic Aid: Revisiting Foundational Mechanisms and Applications.Sports medicine (Auckland, N.Z.) · 2025Review
- Impact of ischemic preconditioning combined with aerobic exercise on 24-h ambulatory blood pressure in men with prehypertension and stage 1 hypertension.Frontiers in physiology · 2024Article
- 2023 TAMIS/TSOC/TACVPR Consensus Statement for Patients with Acute Myocardial Infarction Rehabilitation.Acta Cardiologica Sinica · 2023Article
- Association between engagement in exercise training and peak cardiac biomarker concentrations following ST-elevation myocardial infarction.BMJ open sport & exercise medicine · 2023Article
- Lesson from the Pandemic: People should Always Stay Physically Active.Current cardiology reviews · 2022Article
- Pretreatment of Nicorandil Protects the Heart from Exhaustive Exercise-Induced Myocardial Injury in Rats.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Increased protein S-nitrosylation in mitochondria: a key mechanism of exercise-induced cardioprotection.Basic research in cardiology · 2021Article
- Statin Associated With Physical Training: A Perfect Combination.Arquivos brasileiros de cardiologia · 2021Article
- Preconditioning of Caenorhabditis elegans to anoxic insult by inactivation of cholinergic, GABAergic and muscle activity.Genes, brain, and behavior · 2021Article
- Systolic and Diastolic Functions After a Brief Acute Bout of Mild Exercise in Normobaric Hypoxia.Frontiers in physiology · 2021Article
- Methodological Variations Contributing to Heterogenous Ergogenic Responses to Ischemic Preconditioning.Frontiers in physiology · 2021Review
- The Peripheral Circadian Clock and Exercise: Lessons from Young and Old Mice.Journal of circadian rhythms · 2020Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A great bulk of evidence supports the concept that regular exercise training can reduce the incidence of coronary events and increase survival chances after myocardial infarction. These exercise-induced beneficial effects on the myocardium are reached by means of the reduction of several risk factors relating to cardiovascular disease, such as high cholesterol, hypertension, obesity etc. Furthermore, it has been demonstrated that exercise can reproduce the "ischemic preconditioning" (IP), which refers to the capacity of short periods of ischemia to render the myocardium more resistant to subsequent ischemic insult and to limit infarct size during prolonged ischemia. However, IP is a complex phenomenon which, along with infarct size reduction, can also provide protection against arrhythmia and myocardial stunning due to ischemia-reperfusion. Several clues demonstrate that preconditioning may be directly induced by exercise, thus inducing a protective phenotype at the heart level without the necessity of causing ischemia. Exercise appears to act as a physiological stress that induces beneficial myocardial adaptive responses at cellular level. The purpose of the present paper is to review the latest data on the role played by exercise in triggering myocardial preconditioning.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.