Evidence map›Paper›PMID 24719873›Full record

Trial reportBioMed research international2014

Molecular epidemiology and genotyping of Mycobacterium tuberculosis isolated in Baghdad.

Ruqaya Mustafa Ali, Alberto Trovato, David Couvin, Amina N Al-Thwani, Emanuele Borroni, Fahim H Dhaer, Nalin Rastogi, Daniela M Cirillo

Abstract readClinical TrialComparative Study
In one paragraph

Trial report in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Genetic Diversity of Drug-resistantAdvanced biomedical research · 2018
    Article
  3. Article
  4. Article
  5. Article
  6. Molecular identification ofEuropean academic research · 2016
    Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ruqaya Mustafa AliGenetic Engineering and Biotechnology Institute for Post Graduate Studies, University of Baghdad, 10070 Jadriyah, Baghdad, Iraq.
Alberto TrovatoEmerging Bacterial Pathogens Unit, San Raffaele Scientific Institute (HSR), via Olgettina, 60 20132 Milano, Italy.
David CouvinInstitut Pasteur de la Guadeloupe, Abymes, 97183 Guadeloupe, France.ORCID 0000-0002-7897-9023
Amina N Al-ThwaniGenetic Engineering and Biotechnology Institute for Post Graduate Studies, University of Baghdad, 10070 Jadriyah, Baghdad, Iraq.
Emanuele BorroniEmerging Bacterial Pathogens Unit, San Raffaele Scientific Institute (HSR), via Olgettina, 60 20132 Milano, Italy.ORCID 0000-0001-6780-5119
Fahim H DhaerMinistry of Agriculture, Al Nidhal Street, Baghdad 5157, Iraq.
Nalin RastogiInstitut Pasteur de la Guadeloupe, Abymes, 97183 Guadeloupe, France.ORCID 0000-0002-7199-7747
Daniela M CirilloEmerging Bacterial Pathogens Unit, San Raffaele Scientific Institute (HSR), via Olgettina, 60 20132 Milano, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tuberculosis (TB) remains a major health problem in Iraq but the strains responsible for the epidemic have been poorly characterized. Our aim was to characterize the TB strains circulating in Bagdad (Iraq). A total of 270 Mycobacterium tuberculosis complex (MTBC) strains isolated between 2010 and 2011 from TB patients attending the Center of Chest and Respiratory diseases in Baghdad were analyzed by Spoligotyping. The analysis indicated that 94.1% of the isolates belong to known genotype clades: CAS 39.6%, ill-defined T clade 29.6%, Manu 7.4%, Haarlem 7%, Ural 4.1%, LAM 3.3%, X 0.7%, LAM7-TUR 0.7%, EAI 0.7%, S 0.7%, and unknown 5.9%. Comparison with the international multimarker database SITVIT2 showed that SIT 309 (CAS1-Delhi) and SIT1144 (T1) were the most common types. In addition, 44 strains were included in SITVIT2 database under 16 new Spoligotype International Types (SITs); of these, 6 SITs (SIT3346, SIT3497, SIT3708, SIT3790, SIT3791, and SIT3800) (n = 32 strains) were created within the present study and 10 were created after a match with an orphan in the database. By using 24-loci MIRU-VNTR-typing on a subset of 110 samples we found a high recent transmission index (RTI) of 33.6%. In conclusion, we present the first unifying framework for both epidemiology and evolutionary analysis of M. tuberculosis in Iraq.

Indexed as

GenotypeMolecular EpidemiologyMycobacterium tuberculosisTuberculosisAdultAgedChildChild, PreschoolFemaleHumansInfantInfant, NewbornIraqMaleMiddle Aged

Identifiers

PMID24719873
PMCPMC3955663

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.