ArticleInternational journal of biological sciences2014
Systemic blockage of nitric oxide synthase by L-NAME increases left ventricular systolic pressure, which is not augmented further by Intralipid®.
Article in International journal of biological sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Combined lipid emulsion and plasma exchange in massive pediatric bupropion overdose: Case Report.Frontiers in toxicology · 2025Article
- Direct effect of lipid emulsion treatment on local anesthetic systemic toxicity.Clinical and experimental emergency medicine · 2024Article
- Effect of lipid emulsion on vasoconstriction induced by epinephrine or norepinephrine in isolated rat aorta.Korean journal of anesthesiology · 2024Article
- Lipid emulsion for xenobiotic overdose: PRO.British journal of clinical pharmacology · 2023Article
- Mechanisms underlying lipid emulsion resuscitation for drug toxicity: a narrative review.Korean journal of anesthesiology · 2023Review
- Lipid Emulsion Inhibits Amlodipine-Induced Nitric Oxide-Mediated Vasodilation in Isolated Rat Aorta.International journal of molecular sciences · 2023Article
- Lipid Emulsion to Treat Acute Poisonings: Mechanisms of Action, Indications, and Controversies.Pharmaceutics · 2023Review
- Reply to the letter to the editor.European heart journal. Case reports · 2023Article
- Lipid Emulsion Enhances Vasoconstriction Induced by Dexmedetomidine in the Isolated Endothelium-Intact Aorta.International journal of molecular sciences · 2021Article
- Lipofundin MCT/LCT Inhibits Levcromakalim-Induced Vasodilation by Inhibiting Endothelial Nitric Oxide Release.International journal of molecular sciences · 2020Article
- The Effects of Intravenous Lipid Emulsion Therapy in the Prevention of Depressive Effects of Propofol on Cardiovascular and Respiratory Systems: An Experimental Animal Study.Medicina (Kaunas, Lithuania) · 2018Article
- Linoleic Acid Attenuates the Toxic Dose of Bupivacaine-Mediated Reduction of Vasodilation Evoked by the Activation of Adenosine Triphosphate-Sensitive Potassium Channels.International journal of molecular sciences · 2018Article
- Lipid Emulsion for Treating Local Anesthetic Systemic Toxicity.International journal of medical sciences · 2018Review
- Lipid emulsion inhibits vasodilation induced by a toxic dose of bupivacaine by suppressing bupivacaine-induced PKC and CPI-17 dephosphorylation but has no effect on vasodilation induced by a toxic dose of mepivacaine.The Korean journal of pain · 2016Article
- Lipofundin® MCT/LCT 20% increase left ventricular systolic pressure in an ex vivo rat heart model via increase of intracellular calcium level.Korean journal of anesthesiology · 2016Article
- The effect of hydroalcoholic extract of Achillea eriophora DC. on blood pressure of anaesthetized male rat.EXCLI journal · 2016Article
- Multi-modal contributions to detoxification of acute pharmacotoxicity by a triglyceride micro-emulsion.Journal of controlled release : official journal of the Controlled Release Society · 2015Article
- Lipid Emulsion Inhibits Vasodilation Induced by a Toxic Dose of Bupivacaine via Attenuated Dephosphorylation of Myosin Phosphatase Target Subunit 1 in Isolated Rat Aorta.International journal of medical sciences · 2015Article
- Lipid Emulsion Attenuates Acetylcholine-Induced Relaxation in Isolated Rat Aorta.BioMed research international · 2015Article
- Linolenic Acid Attenuates the Vasodilation Induced by Acetylcholine in Isolated Rat Aortae.Dose-response : a publication of International Hormesis SocietyArticle
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intravenous lipid emulsions (LEs) are effective in the treatment of toxicity associated with various drugs such as local anesthetics and other lipid soluble agents. The goals of this study were to examine the effect of LE on left ventricular hemodynamic variables and systemic blood pressure in an in vivo rat model, and to determine the associated cellular mechanism with a particular focus on nitric oxide. Two LEs (Intralipid(®) 20% and Lipofundin(®) MCT/LCT 20%) or normal saline were administered intravenously in an in vivo rat model following induction of anesthesia by intramuscular injection of tiletamine/zolazepam and xylazine. Left ventricular systolic pressure (LVSP), blood pressure, heart rate, maximum rate of intraventricular pressure increase, and maximum rate of intraventricular pressure decrease were measured before and after intravenous administration of various doses of LEs or normal saline to an in vivo rat with or without pretreatment with the non-specific nitric oxide synthase inhibitor N(ω)-nitro-L-arginine-methyl ester (L-NAME). Administration of Intralipid(®) (3 and 10 ml/kg) increased LVSP and decreased heart rate. Pretreatment with L-NAME (10 mg/kg) increased LSVP and decreased heart rate, whereas subsequent treatment with Intralipid(®) did not significantly alter LVSP. Intralipid(®) (10 ml/kg) increased mean blood pressure and decreased heart rate. The increase in LVSP induced by Lipofundin(®) MCT/LCT was greater than that induced by Intralipid(®). Intralipid(®) (1%) did not significantly alter nitric oxide donor sodium nitroprusside-induced relaxation in endothelium-denuded rat aorta. Taken together, systemic blockage of nitric oxide synthase by L-NAME increases LVSP, which is not augmented further by intralipid(®).
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