Evidence map›Paper›PMID 24719442›Full record

ArticleJournal of clinical microbiology2014

Fungal DNA detected in blood samples of patients who received contaminated methylprednisolone injections reveals increased complexity of causative agents.

Yanan Zhao, Emilian Armeanu, Richard DiVerniero, Terri A Lewis, Richard C Dobson, Dimitrios P Kontoyiannis, Emmanuel Roilides, Thomas J Walsh, David S Perlin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
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  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Yanan ZhaoPublic Health Research Institute Center, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey, USA Exserohilum Meningitis Research Consortium, New York, New York, USA.
Emilian ArmeanuSICC LLC, Evansville, Indiana, USA.
Richard DiVernieroPremier Orthopaedic Associates, Mullica Hill, New Jersey, USA.
Terri A LewisGraduate Institute of Rehabilitation Counseling, National Changhua University of Education, Changhua, Taiwan, China.
Richard C Dobson2117 Buffalo Rd., Suite 124, Rochester, New York, USA.
Dimitrios P KontoyiannisExserohilum Meningitis Research Consortium, New York, New York, USA Department of Infectious Diseases, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Emmanuel RoilidesExserohilum Meningitis Research Consortium, New York, New York, USA 3rd Department of Pediatrics, Faculty of Medicine, Aristotle University School of Health Sciences, Hippokration General Hospital, Salonika, Greece.
Thomas J WalshExserohilum Meningitis Research Consortium, New York, New York, USA Transplantation-Oncology Infectious Diseases Program, Department of Pediatrics, Microbiology & Immunology, Weill Cornell Medical Center, New York, New York, USA.
David S PerlinPublic Health Research Institute Center, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey, USA Exserohilum Meningitis Research Consortium, New York, New York, USA perlinds@njms.rutgers.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Using Exserohilum rostratum-specific and panfungal real-time PCR, we studied 24 blood samples and 2 synovial fluid specimens from 20 patients with persistent or worsening pain following injections of contaminated methylprednisolone. Seven blood specimens from 6 patients were significantly positive for fungal DNA by panfungal PCR, with multiple fungal species identified.

Indexed as

Drug ContaminationGenetic VariationAdultBloodDNA, FungalFemaleFungemiaFungiHumansIatrogenic DiseaseInjections, IntravenousMaleMethylprednisoloneMiddle AgedReal-Time Polymerase Chain ReactionSynovial FluidDNA, FungalMethylprednisolone

Identifiers

PMID24719442
PMCPMC4042738

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.