Evidence map›Paper›PMID 24719434›Full record

ArticleJournal of clinical microbiology2014

Reduction in false-positive Aspergillus serum galactomannan enzyme immunoassay results associated with use of piperacillin-tazobactam in the United States.

Paschalis Vergidis, Raymund R Razonable, L Joseph Wheat, Lynn Estes, Angela M Caliendo, Lindsey R Baden, John R Wingard, John Baddley, Maha Assi, Steven Norris and 8 more

Abstract readCase Reports
In one paragraph

Article in Journal of clinical microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Guideline
  2. Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016
    Guideline
  3. In Vitro Anti-Journal of fungi (Basel, Switzerland) · 2026
    Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Clinical features and cause analysis of false positive results of Aspergillus galactomannan assay in pulmonary cryptococcosis patients.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019
    Article
  12. Article
  13. Strategies for the management of invasive fungal infections due to filamentous fungi in high-risk hemato-oncological patients.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2019
    Article
  14. Article
  15. Review
  16. Article
  17. Role of Molecular Biomarkers in the Diagnosis of Invasive Fungal Diseases in Children.Journal of the Pediatric Infectious Diseases Society · 2017
    Review
  18. Medical mycology case reports · 2017
    Article
  19. Review
  20. CirculatingFrontiers in microbiology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Paschalis VergidisMayo Clinic College of Medicine, Rochester, Minnesota, USA.
Raymund R RazonableMayo Clinic College of Medicine, Rochester, Minnesota, USA.
L Joseph WheatMiraVista Diagnostics and Mirabella Technologies, Indianapolis, Indiana, USA.
Lynn EstesMayo Clinic College of Medicine, Rochester, Minnesota, USA.
Angela M CaliendoAlpert Medical School of Brown University, Providence, Rhode Island, USA.
Lindsey R BadenBrigham and Women's Hospital, Boston, Massachusetts, USA.
John R WingardUniversity of Florida, College of Medicine, Gainesville, Florida, USA.
John BaddleyUniversity of Alabama, Birmingham, Alabama, USA.
Maha AssiUniversity of Kansas School of Medicine, Wichita, Kansas, USA.
Steven NorrisCommunity Infectious Diseases, Indianapolis, Indiana, USA.
Pranatharthi ChandrasekarWayne State University, Detroit, Michigan, USA.
Ryan ShieldsUniversity of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Hong NguyenUniversity of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Alison FreifeldUniversity of Nebraska Medical Center, Omaha, Nebraska, USA.
Richard KohlerIndiana University, Infectious Diseases, Wishard Memorial Hospital, Indianapolis, Indiana, USA.
Martin KleimanIndiana University, Pediatric Infectious Diseases, Riley Memorial Hospital, Indianapolis, Indiana, USA.
Thomas J WalshWeill Cornell Medical Center, New York, New York, USA.
Chadi A HageIndiana University, Thoracic Transplantation Program, Indianapolis, Indiana, USA chage@iu.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Piperacillin-tazobactam (PTZ) is known to cause false-positive results in the Platelia Aspergillus enzyme-linked immunoassay (EIA), due to contamination with galactomannan (GM). We tested 32 lots of PTZ and 27 serum specimens from patients receiving PTZ. GM was not detected in the lots of PTZ; one serum specimen (3.7%) was positive. PTZ formulations commonly used in the United States today appear to be a rare cause for false-positive GM results.

Indexed as

False Positive ReactionsAged, 80 and overAnti-Bacterial AgentsAspergillosisAspergillusDiagnostic Tests, RoutineDrug ContaminationFemaleGalactoseHumansImmunoenzyme TechniquesMannansPenicillanic AcidPiperacillinPiperacillin, Tazobactam Drug CombinationSerumAnti-Bacterial AgentsgalactomannanGalactoseMannansPenicillanic AcidPiperacillinPiperacillin, Tazobactam Drug Combination

Identifiers

PMID24719434
PMCPMC4042793

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.