ArticleChembiochem : a European journal of chemical biology2014
Cellular scent of influenza virus infection.
Article in Chembiochem : a European journal of chemical biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it, 92 citations in OpenAlex.
- A comprehensive meta-analysis and systematic review of breath analysis in detection of COVID-19 through Volatile organic compounds.Diagnostic microbiology and infectious disease · 2024Pooled it
- Scent dog identification of SARS-CoV-2 infections in different body fluids.BMC infectious diseases · 2021Trial
- Olfactory Science and Technology in Prostate Cancer Diagnosis: From Invertebrate Models to Artificial Intelligence.Life (Basel, Switzerland) · 2026Review
- Measurement of immune cell-derived volatile organic compounds from ex vivo and in vitro cultures: a scoping review.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Trained Scent Dog Detection and GC-MS Analysis of Volatile Organic Compounds from Murine Coronavirus-Infected Cell Cultures.Animals : an open access journal from MDPI · 2026Article
- Dogs' Detection of Symptomatic and Asymptomatic SARS-CoV-2 by Non-Working Dogs: Feasibility and Limits Under Controlled Laboratory Conditions.Animals : an open access journal from MDPI · 2026Article
- Volatile Organic Compounds Induced upon Viral Infection in Cell Culture: Uniform Background Study with Use of Viruses from Different Families.Molecules (Basel, Switzerland) · 2025Article
- Bioreactor contamination monitoring using off-gassed volatile organic compounds (VOCs).Analytical and bioanalytical chemistry · 2025Article
- Zika virus modulates human fibroblasts to enhance transmission success in a controlled lab-setting.Communications biology · 2025Article
- Article
- High and low pathogenicity avian influenza virus discrimination and prediction based on volatile organic compounds signature by SIFT-MS: a proof-of-concept study.Scientific reports · 2024Article
- Tuning phosphorene and MoSRSC advances · 2024Article
- A feasibility study on exhaled breath analysis using UV spectroscopy to detect COVID-19.Journal of breath research · 2023Article
- Rapid point-of-care detection of SARS-CoV-2 infection in exhaled breath using ion mobility spectrometry: a pilot study.European journal of medical research · 2023Article
- Early Events after Herpes Simplex Virus-Type 1 Entry Are Necessary for the Release of Gamma-Hydroxybutyrate upon Acute Infection.Pharmaceuticals (Basel, Switzerland) · 2023Article
- iOBPdb A Database for Experimentally Determined Functional Characterization of Insect Odorant Binding Proteins.Scientific data · 2023Article
- Predominant SARS-CoV-2 variant impacts accuracy when screening for infection using exhaled breath vapor.Communications medicine · 2022Article
- Breath Biomarkers of Influenza Infection.Open forum infectious diseases · 2022Article
- Clinical studies of detecting COVID-19 from exhaled breath with electronic nose.Scientific reports · 2022Article
- Diagnostic accuracy of non-invasive detection of SARS-CoV-2 infection by canine olfaction.PloS one · 2022Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Volatile organic compounds (VOCs) emanating from humans have the potential to revolutionize non-invasive diagnostics. Yet, little is known about how these compounds are generated by complex biological systems, and even less is known about how these compounds are reflective of a particular physiological state. In this proof-of-concept study, we examined VOCs produced directly at the cellular level from B lymphoblastoid cells upon infection with three live influenza virus subtypes: H9N2 (avian), H6N2 (avian), and H1N1 (human). Using a single cell line helped to alleviate some of the complexity and variability when studying VOC production by an entire organism, and it allowed us to discern marked differences in VOC production upon infection of the cells. The patterns of VOCs produced in response to infection were unique for each virus subtype, while several other non-specific VOCs were produced after infections with all three strains. Also, there was a specific time course of VOC release post infection. Among emitted VOCs, production of esters and other oxygenated compounds was particularly notable, and these may be attributed to increased oxidative stress resulting from infection. Elucidating VOC signatures that result from the host cells response to infection may yield an avenue for non-invasive diagnostics and therapy of influenza and other viral infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.