Trial reportJournal of magnetic resonance imaging : JMRI2014
High resolution in vivo characterization of apparent diffusion coefficient at the tumor-stromal boundary of breast carcinomas: a pilot study to assess treatment response using proximity-dependent diffusion-weighted imaging.
Trial report in Journal of magnetic resonance imaging : JMRI, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of peritumoral region features assessed on breast MRI and prognosis of breast cancer: a systematic review and meta-analysis.European radiology · 2024Pooled it
- Diffusion Tensor Imaging for Characterizing Changes in Triple-Negative Breast Cancer During Neoadjuvant Systemic Therapy.Journal of magnetic resonance imaging : JMRI · 2024Article
- The Potential Role of the Fat-Glandular Interface (FGI) in Breast Carcinogenesis: Results from an Ultrasound Tomography (UST) Study.Journal of clinical medicine · 2021Article
- Article
- Review
- Multiphase matrix of silica, culture medium and air for 3D mammalian cell culture.Cytotechnology · 2020Article
- Association of Peritumoral Radiomics With Tumor Biology and Pathologic Response to Preoperative Targeted Therapy for HER2 (ERBB2)-Positive Breast Cancer.JAMA network open · 2019Article
- Quantitative analysis of peri-tumor fat in different molecular subtypes of breast cancer.Magnetic resonance imaging · 2018Article
- The utility of measuring the apparent diffusion coefficient for peritumoral zone in assessing infiltration depth of endometrial cancer.Cancer imaging : the official publication of the International Cancer Imaging Society · 2018Article
- Heterogeneity of Diffusion-Weighted Imaging in Tumours and the Surrounding Stroma for Prediction of Ki-67 Proliferation Status in Breast Cancer.Scientific reports · 2017Article
- Diffusion-weighted breast MRI: Clinical applications and emerging techniques.Journal of magnetic resonance imaging : JMRI · 2017Review
- Diffusion-weighted imaging of breast tumours at 3 Tesla and 7 Tesla: a comparison.European radiology · 2016Article
- Dynamic properties of water in breast pathology depend on the histological compounds: distinguishing tissue malignancy by water diffusion coefficients.BMC research notes · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
purposeTo evaluate diffusion changes in the breast tumor-stromal boundary and adjacent tissue in response to neoadjuvant chemotherapy using high resolution diffusion-weighted imaging (HR-DWI). MATERIALS AND
methodsSeven patients with invasive breast cancer were imaged with HR-DWI before and early during treatment. The mean apparent diffusion coefficient (ADC) was plotted in 1-mm increments around the tumor boundary. Early change in ADC was measured for tumor, tumor boundary, and stromal regions, and the relationship to treatment response was evaluated using Spearman's correlation.
resultsStatistically significant correlations between treatment response and early changes in ADC were found for: (i) whole tumor (ρ = 0.93, 95% confidence interval [CI] = (0.58, 0.99), P = 0.003); (ii) tumor rim (ρ = 0.75, 95% CI = (-0.007, 0.96), P = 0.05); and (iii) boundary transition region (ρ = 0.86, 95% CI = (0.29, 0.98), P = 0.01). Early change in ADC of distal stroma had a marginally statistically significant positive correlation to treatment response (ρ = 0.71, 95% CI = (-0.084, 0.95), P = 0.07).
conclusionProximity-dependent evaluation of HR-DWI data in the breast tumor-stromal boundary and adjacent tissue may provide information about response to therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.