ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Action potential generation in an anatomically constrained model of medial superior olive axons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Axon initial segment dynamics during associative fear learning.Nature neuroscience · 2026Article
- Axon initial segment plasticity caused by auditory deprivation degrades time difference sensitivity in a model of neural responses to cochlear implants.Journal of computational neuroscience · 2025Article
- A mammalian inferior colliculus model for sound source separation using interaural time differences.PLoS computational biology · 2025Article
- Experience-Dependent Plasticity in Nucleus Laminaris of the Barn Owl.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Connecting Connectomes to Physiology.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Review
- Structure and dynamics that specialize neurons for high-frequency coincidence detection in the barn owl nucleus laminaris.Biological cybernetics · 2023Article
- Ambient noise exposure induces long-term adaptations in adult brainstem neurons.Scientific reports · 2021Article
- Arrangement of Excitatory Synaptic Inputs on Dendrites of the Medial Superior Olive.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Soma-axon coupling configurations that enhance neuronal coincidence detection.PLoS computational biology · 2019Article
- Distinct Distribution Patterns of Potassium Channel Sub-Units in Somato-Dendritic Compartments of Neurons of the Medial Superior Olive.Frontiers in cellular neuroscience · 2019Article
- Axonal Computations.Frontiers in cellular neuroscience · 2019Review
- Function and energy consumption constrain neuronal biophysics in a canonical computation: Coincidence detection.PLoS computational biology · 2018Article
- Extraction of Inter-Aural Time Differences Using a Spiking Neuron Network Model of the Medial Superior Olive.Frontiers in neuroscience · 2018Article
- Sound-Evoked Activity Influences Myelination of Brainstem Axons in the Trapezoid Body.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Physiology and anatomy of neurons in the medial superior olive of the mouse.Journal of neurophysiology · 2016Article
- Low Somatic Sodium Conductance Enhances Action Potential Precision in Time-Coding Auditory Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Serotonin modulates spike probability in the axon initial segment through HCN channels.Nature neuroscience · 2016Article
- Neuronal coupling by endogenous electric fields: cable theory and applications to coincidence detector neurons in the auditory brain stem.Journal of neurophysiology · 2016Article
- Computer Simulations Support a Morphological Contribution to BDNF Enhancement of Action Potential Generation.Frontiers in cellular neuroscience · 2016Article
- Decreased temporal precision of neuronal signaling as a candidate mechanism of auditory processing disorder.Hearing research · 2015Review
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurons in the medial superior olive (MSO) encode interaural time differences (ITDs) with sustained firing rates of >100 Hz. They are able to generate such high firing rates for several hundred milliseconds despite their extremely low-input resistances of only few megaohms and high synaptic conductances in vivo. The biophysical mechanisms by which these leaky neurons maintain their excitability are not understood. Since action potentials (APs) are usually assumed to be generated in the axon initial segment (AIS), we analyzed anatomical data of proximal MSO axons in Mongolian gerbils and found that the axon diameter is <1 μm and the internode length is ∼100 μm. Using a morphologically constrained computational model of the MSO axon, we show that these thin axons facilitate the excitability of the AIS. However, for ongoing high rates of synaptic inputs the model generates a substantial fraction of APs in its nodes of Ranvier. These distally initiated APs are mediated by a spatial gradient of sodium channel inactivation and a strong somatic current sink. The model also predicts that distal AP initiation increases the dynamic range of the rate code for ITDs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.