ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
DRD1 and DRD2 genotypes modulate processing modes of goal activation processes during action cascading.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Dopamine Modulates the Efficiency of Sensory Evidence Accumulation During Perceptual Decision Making.The international journal of neuropsychopharmacology · 2018Trial
- γ-Aminobutyric acid (GABA) administration improves action selection processes: a randomised controlled trial.Scientific reports · 2015Trial
- The influence of dopamine receptor SNPs on substance use disorder in a Jordanian cohort.BMC research notes · 2025Article
- Modality-specific and modality-independent neural representations work in concert in predictive processes during sequence learning.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- On the relative importance of attention and response selection processes for multi-component behavior - Evidence from EEG-based deep learning.Neuroimage. Reports · 2022Article
- A Metacontrol Perspective on Neurocognitive Atypicality: From Unipolar to Bipolar Accounts.Frontiers in psychiatry · 2022Article
- Article
- Potential Prognostic Impact of Dopamine Receptor D1 (Frontiers in neurology · 2021Article
- Impact of dopamine-related genetic variants on physical activity in old age - a cohort study.The international journal of behavioral nutrition and physical activity · 2020Article
- Immediate early gene fingerprints of multi-component behaviour.Scientific reports · 2020Article
- Backward Walking and Dual-Task Assessment Improve Identification of Gait Impairments and Fall Risk in Individuals with MS.Multiple sclerosis international · 2020Article
- The Role of DRD1 and DRD2 Receptors for Response Selection Under Varying Complexity Levels: Implications for Metacontrol Processes.The international journal of neuropsychopharmacology · 2019Article
- Methamphetamine Users Show No Behavioral Deficits in Response Selection After Protracted Abstinence.Frontiers in psychiatry · 2019Article
- Dual-Tasking in Multiple Sclerosis - Implications for a Cognitive Screening Instrument.Frontiers in human neuroscience · 2018Article
- Neural mechanisms underlying successful and deficient multi-component behavior in early adolescent ADHD.NeuroImage. Clinical · 2018Article
- Sensory processes modulate differences in multi-component behavior and cognitive control between childhood and adulthood.Human brain mapping · 2017Article
- Humans with latent toxoplasmosis display altered reward modulation of cognitive control.Scientific reports · 2017Article
- Evidence for enhanced multi-component behaviour in Tourette syndrome - an EEG study.Scientific reports · 2017Article
- On the effects of multimodal information integration in multitasking.Scientific reports · 2017Article
- The Roles of Dopamine D2 Receptor in the Social Hierarchy of Rodents and Primates.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dopamine plays an important role in action selection, but little is known about the influence of different dopamine receptor systems on the subprocesses occurring during the cascading of actions. Because action selection and cascading can be accomplished in a serial manner or a parallel manner, we investigated the potential effects of DRD1 (rs4531) and DRD2 (rs6277) receptor polymorphisms on this dimension. We gathered behavioral and neurophysiological data from healthy human subjects (n = 162) and applied mathematical constraints to quantify their action selection strategy on a serial-parallel continuum. The behavioral results show a more serial and more effective action cascading strategy in homozygous DRD1 G allele carriers, who are assumed to have a higher D1 receptor efficiency than carriers of the A allele. In the group of homozygous DRD2 T-allele carriers, who have a higher striatal density of D2 receptors than C-allele carriers, we found a less effective and more parallel action cascading strategy. These findings suggest that, within the same sample, a higher D1 efficiency seems to shift the action cascading strategy toward a more serial processing mode, whereas the D2 receptors seem to promote a shift in the opposite direction by inducing a more parallel processing mode. Furthermore, the neurophysiological analysis shows that the observed differences are not based on attentional differences or basic inhibition. Instead, processes linking stimulus processing and response execution seem to differentiate between more serial and more parallel processing groups.
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