ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Snail coordinately regulates downstream pathways to control multiple aspects of mammalian neural precursor development.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Functional Transcription Factor Target Networks Illuminate Control of Epithelial Remodelling.Cancers · 2020Article
- Article
- Brain expansion promoted by polycomb-mediated anterior enhancement of a neural stem cell proliferation program.PLoS biology · 2019Article
- Regulation of Polarity Protein Levels in the Developing Central Nervous System.Journal of molecular biology · 2018Review
- Endothelial HIF-2α contributes to severe pulmonary hypertension due to endothelial-to-mesenchymal transition.American journal of physiology. Lung cellular and molecular physiology · 2018Article
- Potential Involvement of Snail Members in Neuronal Survival and Astrocytic Migration during the Gecko Spinal Cord Regeneration.Frontiers in cellular neuroscience · 2017Article
- A flexible genetic toolkit for arthropod neurogenesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- The evolution of early neurogenesis.Developmental cell · 2015Review
- Conditional ablation of p63 indicates that it is essential for embryonic development of the central nervous system.Cell cycle (Georgetown, Tex.) · 2015Article
- Polarity transitions during neurogenesis and germinal zone exit in the developing central nervous system.Frontiers in cellular neuroscience · 2015Review
- The Snail transcription factor regulates the numbers of neural precursor cells and newborn neurons throughout mammalian life.PloS one · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The Snail transcription factor plays a key role in regulating diverse developmental processes but is not thought to play a role in mammalian neural precursors. Here, we have examined radial glial precursor cells of the embryonic murine cortex and demonstrate that Snail regulates their survival, self-renewal, and differentiation into intermediate progenitors and neurons via two distinct and separable target pathways. First, Snail promotes cell survival by antagonizing a p53-dependent death pathway because coincident p53 knockdown rescues survival deficits caused by Snail knockdown. Second, we show that the cell cycle phosphatase Cdc25b is regulated by Snail in radial precursors and that Cdc25b coexpression is sufficient to rescue the decreased radial precursor proliferation and differentiation observed upon Snail knockdown. Thus, Snail acts via p53 and Cdc25b to coordinately regulate multiple aspects of mammalian embryonic neural precursor biology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.