ArticleFunctional & integrative genomics2014
A genome-wide survey reveals a deletion polymorphism associated with resistance to gastrointestinal nematodes in Angus cattle.
Article in Functional & integrative genomics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- A large structural variant collection in Holstein cattle and associated database for variant discovery, characterization, and application.BMC genomics · 2024Article
- Structural variations in livestock genomes and their associations with phenotypic traits: a review.Frontiers in veterinary science · 2024Review
- Advancements in copy number variation screening in herbivorous livestock genomes and their association with phenotypic traits.Frontiers in veterinary science · 2023Review
- Copy number variant-based genome wide association study reveals immune-related genes associated with parasite resistance in a heritage sheep breed from the United States.Parasite immunology · 2022Article
- Towards the detection of copy number variation from single sperm sequencing in cattle.BMC genomics · 2022Article
- Article
- Genome-wide associations and functional gene analyses for endoparasite resistance in an endangered population of native German Black Pied cattle.BMC genomics · 2019Article
- Probe-based association analysis identifies several deletions associated with average daily gain in beef cattle.BMC genomics · 2019Article
- Characterization of copy number variants in a large multibreed population of beef and dairy cattle using high-density single nucleotide polymorphism genotype data.Journal of animal science · 2018Article
- Integrating CNVs into meta-QTL identified GBP4 as positional candidate for adult cattle stature.Functional & integrative genomics · 2018Article
- Inflammasomes in livestock and wildlife: Insights into the intersection of pathogens and natural host species.Veterinary immunology and immunopathology · 2018Review
- Genomic predictions combining SNP markers and copy number variations in Nellore cattle.BMC genomics · 2018Article
- Association study between copy number variation and beef fatty acid profile of Nellore cattle.Journal of applied genetics · 2018Article
- Copy number variations and genome-wide associations reveal putative genes and metabolic pathways involved with the feed conversion ratio in beef cattle.Journal of applied genetics · 2016Article
- Breeding for resistance to gastrointestinal nematodes - the potential in low-input/output small ruminant production systems.Veterinary parasitology · 2016Review
- Comparative analyses across cattle genders and breeds reveal the pitfalls caused by false positive and lineage-differential copy number variations.Scientific reports · 2016Article
- Genome-wide copy number variation (CNV) detection in Nelore cattle reveals highly frequent variants in genome regions harboring QTLs affecting production traits.BMC genomics · 2016Article
- Genome-wide CNV analysis reveals variants associated with growth traits in Bos indicus.BMC genomics · 2016Article
- Use of Genomic Tools to Improve Cattle Health in the Context of Infectious Diseases.Frontiers in genetics · 2016Review
- Copy number variation-based genome wide association study reveals additional variants contributing to meat quality in Swine.Scientific reports · 2015Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gastrointestinal (GI) nematode infections are a worldwide threat to human health and animal production. In this study, we performed a genome-wide association study between copy number variations (CNVs) and resistance to GI nematodes in an Angus cattle population. Using a linear regression analysis, we identified one deletion CNV which reaches genome-wide significance after Bonferroni correction. With multiple mapped human olfactory receptor genes but no annotated bovine genes in the region, this significantly associated CNV displays high population frequencies (58.26 %) with a length of 104.8 kb on chr7. We further investigated the linkage disequilibrium (LD) relationships between this CNV and its nearby single nucleotide polymorphisms (SNPs) and genes. The underlining haplotype blocks contain immune-related genes such as ZNF496 and NLRP3. As this CNV co-segregates with linked SNPs and associated genes, we suspect that it could contribute to the detected variations in gene expression and thus differences in host parasite resistance.
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