ArticlePloS one2014
Poor lung function has inverse relationship with microalbuminuria, an early surrogate marker of kidney damage and atherosclerosis: the 5th Korea National Health and Nutrition Examination Survey.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Microalbuminuria in patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis.The Indian journal of medical research · 2026Pooled it
- Inorganic arsenic and respiratory health, from early life exposure to sex-specific effects: A systematic review.Environmental research · 2016Pooled it
- Prevalence and prognostic value of elevated urinary albumin excretion in patients with asthma: analysis of NHANES 2001-2018.BMC pulmonary medicine · 2025Article
- Associations between spirometric impairments and microvascular complications in type 2 diabetes: a cross-sectional study.BMJ open · 2023Article
- Mutual Effects of Coincident Chronic Renal Failure and Chronic Obstructive Pulmonary Disease.Tanaffos · 2023Article
- Lung Dysfunction and Chronic Kidney Disease: A Complex Network of Multiple Interactions.Journal of personalized medicine · 2023Review
- Exercise intolerance in kidney diseases: physiological contributors and therapeutic strategies.American journal of physiology. Renal physiology · 2021Review
- Relationship between pulmonary function and albuminuria in type 2 diabetic patients with preserved renal function.BMC endocrine disorders · 2020Article
- Low lung function and the risk of incident chronic kidney disease in the Malmö Preventive Project cohort.BMC nephrology · 2020Article
- Relationship between pulmonary function and brachial-ankle pulse wave velocity in coal miners in northern China.Journal of thoracic disease · 2019Article
- Albuminuria, Lung Function Decline, and Risk of Incident Chronic Obstructive Pulmonary Disease. The NHLBI Pooled Cohorts Study.American journal of respiratory and critical care medicine · 2019Article
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- Lung Function and Incident Kidney Disease: The Atherosclerosis Risk in Communities (ARIC) Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2017Article
- Lung function and impaired kidney function in relation to metabolic syndrome.International urology and nephrology · 2017Article
- Indoor air pollution and its association with poor lung function, microalbuminuria and variations in blood pressure among kitchen workers in India: a cross-sectional study.Environmental health : a global access science source · 2017Article
- Rapid decline in lung function in healthy adults predicts incident excess urinary albumin excretion later in life.BMJ open respiratory research · 2017Article
- Glomerular filtration rate affects interpretation of pulmonary function test in a Korean general population: results from the Korea National Health and Nutrition Examination Survey 2010 to 2012.The Korean journal of internal medicine · 2016Article
- Obstructive and Restrictive Lung Function Measures and CKD: National Health and Nutrition Examination Survey (NHANES) 2007-2012.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2016Article
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Abstract
backgroundDespite epidemiological evidences of relationship between poor lung function and atherosclerosis, the relationship between poor lung function and microalbuminuria (MAU), an early surrogate marker of both kidney damage and atherosclerosis, is not well understood. Hence, we plan to investigate the relationship between poor lung function and MAU using multivariate models to adjust for other atherogenic risk factors.
methodsWe used data from the 5th Korean National Health and Nutrition Examination Survey. Poor lung function is determined by spirometric measurement, primarily through estimation of the forced vital capacity (FVC) and forced expiratory volume in 1 second (FEV1). Declines in the percent predicted FVC (<80%) and in the FEV1/FVC ratio (<0.7) are defined as restrictive and obstructive patterns, respectively. Urine albumin to urine creatinine levels ratio (UACR) were measured in spot urine samples. MAU was defined as UACR >30 mg/g.
resultsInverse relationship was observed between lung function and UACR. In an age-adjusted regression model, the regression coefficient (B) of 10% lower FVC was 11.09 in men (P = 0.002), which remained significant after adjustment for SBP, FBG, triglyceride level, BMI, smoking history, and heavy alcohol consumption (B = 7.52, P = 0.043). When the restrictive pattern was compared to the normal pattern, the odds ratios (OR) (95% confidence interval, 95%CI) for MAU were 1.90 (1.32-2.72) in men, after adjustment for age, hypertension, diabetes mellitus, triglyceride level, obesity, smoking history, physical activity, and heavy alcohol consumption.
conclusionsOur study, the first investigation in Asia, demonstrated that the restrictive pattern is related to MAU in men. Furthermore, there was linear relationship between lower FVC and UACR. Thus, our current study suggests that poor lung function, particularly the restrictive pattern, is related to kidney damage as well as atherosclerosis.
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