ArticlePloS one2014
Polymorphisms of immunity genes and susceptibility to otitis media in children.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Genetic polymorphisms in human CXJournal of neuroinflammation · 2025Article
- The ECRG4 cleavage product augurin binds the endotoxin receptor and influences the innate immune response during otitis media.Frontiers in genetics · 2022Article
- Immunomodulation as a Protective Strategy in Chronic Otitis Media.Frontiers in cellular and infection microbiology · 2022Article
- Interactions of genetic variants and prenatal stress in relation to the risk for recurrent respiratory infections in children.Scientific reports · 2021Article
- Role of Endoplasmic Reticulum Stress in Otitis Media.Frontiers in genetics · 2020Article
- Genomics of Otitis Media (OM): Molecular Genetics Approaches to Characterize Disease Pathophysiology.Frontiers in genetics · 2020Review
- Recent Perspectives on Gene-Microbe Interactions Determining Predisposition to Otitis Media.Frontiers in genetics · 2019Review
- Panel 3: Genetics and Precision Medicine of Otitis Media.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2017Review
- TLR2 promotes macrophage recruitment and Streptococcus pneumoniae clearance during mouse otitis media.Pediatric research · 2016Article
- Both canonical and non-canonical NF-κB activation contribute to the proliferative response of the middle ear mucosa during bacterial infection.Innate immunity · 2016Article
- Genome-wide association analysis reveals variants on chromosome 19 that contribute to childhood risk of chronic otitis media with effusion.Scientific reports · 2016Article
- Association of cytokine gene polymorphisms and risk factors with otitis media proneness in children.European journal of pediatrics · 2016Article
- A Celebration of the Life and Work of Caroline Breese Hall, MD.Journal of the Pediatric Infectious Diseases Society · 2016Article
- Evidence and evidence gaps in the treatment of Eustachian tube dysfunction and otitis media.GMS current topics in otorhinolaryngology, head and neck surgery · 2016Review
- Genetic Polymorphisms of Functional Candidate Genes and Recurrent Acute Otitis Media With or Without Tympanic Membrane Perforation.Medicine · 2015Observational
- Importance of viruses in acute otitis media.Current opinion in pediatrics · 2015Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundAcute otitis media (OM) is a common disease which often develops through complex interactions between the host, the pathogen and environmental factors. We studied single nucleotide polymorphisms (SNPs) of genes involved in innate and adaptive immunity, and other host and environmental factors for their role in OM.
methodsUsing Sequenom Massarray platform, 21 SNPs were studied in 653 children from prospective (n = 202) and retrospective (n = 451) cohorts. Data were analyzed for the relationship between SNPs and upper respiratory infection (URI) frequency, risk of acute OM during URI episodes, and proneness to recurrent OM.
resultsIncreased risk for OM proneness was associated with CX3CR1 (Thr280Met) SNP and with a jointly interactive group of IL-10 (-1082) SNP, IL-1β (-511) wild type genotype and white race. Family history of OM proneness independently increased the risk for frequent URIs, OM occurrence during URI, and OM proneness. Additionally, IL-1β (-31) SNP was associated with increased risk for frequent URIs, but IL-10 (-592), IL-1β (-511), IL-5 (-746) and IL-8 (-251) SNPs were associated with decreased risk of URI.
conclusionIL-1β (-31), CX3CR1 (Thr280Met), IL-10 (-1082) and IL-1β (-511) SNPs were associated with increased risk for frequent URIs or OM proneness.
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