ArticlePloS one2014
Identification of thyroid carcinoma related genes with mRMR and shortest path approaches.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
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- MRPL15 is a novel prognostic biomarker and therapeutic target for epithelial ovarian cancer.Cancer medicine · 2021Article
- Identification of immune-related lncRNAs to improve the prognosis prediction for patients with papillary thyroid cancer.Bioscience reports · 2021Article
- Deep Learning in Head and Neck Tumor Multiomics Diagnosis and Analysis: Review of the Literature.Frontiers in genetics · 2021Review
- Identification and Validation of a Novel RNA-Binding Protein-Related Gene-Based Prognostic Model for Multiple Myeloma.Frontiers in genetics · 2021Article
- Screening for Core Genes Related to Pathogenesis of Alzheimer's Disease.Frontiers in cell and developmental biology · 2021Article
- Transcriptome and Gene Fusion Analysis of Synchronous Lesions Reveals lncMRPS31P5 as a Novel Transcript Involved in Colorectal Cancer.International journal of molecular sciences · 2020Article
- TargetCPP: accurate prediction of cell-penetrating peptides from optimized multi-scale features using gradient boost decision tree.Journal of computer-aided molecular design · 2020Article
- Article
- Downregulation of RASAL2 promotes the proliferation, epithelial-mesenchymal transition and metastasis of colorectal cancer cells.Oncology letters · 2017Article
- Genome-wide linkage and association analysis of cardiometabolic phenotypes in Hispanic Americans.Journal of human genetics · 2017Article
- Bioinformatics analysis of key genes and latent pathway interactions based on the anaplastic thyroid carcinoma gene expression profile.Oncology letters · 2017Article
- miR-136 suppresses tumor invasion and metastasis by targeting RASAL2 in triple-negative breast cancer.Oncology reports · 2016Article
- Analysis and Identification of Aptamer-Compound Interactions with a Maximum Relevance Minimum Redundancy and Nearest Neighbor Algorithm.BioMed research international · 2016Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thyroid cancer is a malignant neoplasm originated from thyroid cells. It can be classified into papillary carcinomas (PTCs) and anaplastic carcinomas (ATCs). Although ATCs are in an very aggressive status and cause more death than PTCs, their difference is poorly understood at molecular level. In this study, we focus on the transcriptome difference among PTCs, ATCs and normal tissue from a published dataset including 45 normal tissues, 49 PTCs and 11 ATCs, by applying a machine learning method, maximum relevance minimum redundancy, and identified 9 genes (BCL2, MRPS31, ID4, RASAL2, DLG2, MY01B, ZBTB5, PRKCQ and PPP6C) and 1 miscRNA (miscellaneous RNA, LOC646736) as important candidates involved in the progression of thyroid cancer. We further identified the protein-protein interaction (PPI) sub network from the shortest paths among the 9 genes in a PPI network constructed based on STRING database. Our results may provide insights to the molecular mechanism of the progression of thyroid cancer.
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