ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2014
Dopamine function in cigarette smokers: an [¹⁸F]-DOPA PET study.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- EANM practice guideline/SNMMI procedure standard for dopaminergic imaging in Parkinsonian syndromes 1.0.European journal of nuclear medicine and molecular imaging · 2020Guideline
- Tobacco smoking and dopaminergic function in humans: a meta-analysis of molecular imaging studies.Psychopharmacology · 2019Pooled it
- Striatal dopaminergic function and cortical functional connectivity in 22q11.2 deletion syndrome: an integrative multimodalMolecular psychiatry · 2026Article
- Effort and substance use: differentiating tobacco use through reinforcement learning of effort based decision making.Journal of computational neuroscience · 2026Article
- Similarities and Differences in Neurobiology.Advances in experimental medicine and biology · 2025Review
- Dopamine signaling enriched striatal gene set predicts striatal dopamine synthesis and physiological activity in vivo.Nature communications · 2024Article
- Article
- Striatal dopaminergic alterations in individuals with copy number variants at the 22q11.2 genetic locus and their implications for psychosis risk: a [18F]-DOPA PET study.Molecular psychiatry · 2023Article
- Striatal dopamine synthesis capacity and neuromelanin in the substantia nigra: A multimodal imaging study in schizophrenia and healthy controls.Neuroscience applied · 2023Article
- The Relationship Between Frontostriatal Connectivity and Striatal Dopamine Function in Schizophrenia: An 18F-DOPA PET and Diffusion Tensor Imaging Study in Treatment Responsive and Resistant Patients.Psychiatry investigation · 2022Article
- Dopamine dysregulation in psychotic relapse after antipsychotic discontinuation: an [Molecular psychiatry · 2021Article
- The relationship between grey matter volume and striatal dopamine function in psychosis: a multimodalMolecular psychiatry · 2021Article
- Dopamine and Glutamate in Antipsychotic-Responsive Compared With Antipsychotic-Nonresponsive Psychosis: A Multicenter Positron Emission Tomography and Magnetic Resonance Spectroscopy Study (STRATA).Schizophrenia bulletin · 2021Article
- The role of dopamine dysregulation and evidence for the transdiagnostic nature of elevated dopamine synthesis in psychosis: a positron emission tomography (PET) study comparing schizophrenia, delusional disorder, and other psychotic disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Amphetamine-induced striatal dopamine release in schizotypal personality disorder.Psychopharmacology · 2020Article
- Glutamatergic and dopaminergic function and the relationship to outcome in people at clinical high risk of psychosis: a multi-modal PET-magnetic resonance brain imaging study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- The effects of psychosocial stress on dopaminergic function and the acute stress response.eLife · 2019Article
- The effect of a genetic variant at the schizophrenia associated AS3MT/BORCS7 locus on striatal dopamine function: A PET imaging study.Psychiatry research. Neuroimaging · 2019Article
- Neuroimaging of reward mechanisms in Gambling disorder: an integrative review.Molecular psychiatry · 2019Review
- Covariance statistics and network analysis of brain PET imaging studies.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
Tobacco addiction is a global public health problem. Addiction to tobacco is thought to involve the effects of nicotine on the dopaminergic system. Only one study has previously investigated dopamine synthesis capacity in cigarette smokers. This study, exclusively in male volunteers, reported increased dopamine synthesis capacity in heavy smokers compared with non-smokers. We sought to determine whether dopamine synthesis capacity was elevated in a larger sample of cigarette smokers that included females. Dopamine synthesis capacity was measured in 15 daily moderate smokers with 15 sex- and age-matched control subjects who had never smoked tobacco. Dopamine synthesis capacity (indexed as the influx rate constant K(i)(cer)) was measured with positron emission tomography and 3,4-dihydroxy-6-[(18)F]-fluoro-l-phenylalanine. There was no significant group difference in dopamine synthesis capacity between smokers and non-smoker controls in the whole striatum (t28=0.64, p=0.53) or any of its functional subdivisions. In smokers, there were no significant relationships between the number of cigarettes smoked per day and dopamine synthesis capacity in the whole striatum (r=-0.23, p=0.41) or any striatal subdivision. These findings indicate that moderate smoking is not associated with altered striatal dopamine synthesis capacity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.