ArticlePloS one2014
Diffusion tensor imaging and resting-state functional MRI-scanning in 5- and 6-year-old children: training protocol and motion assessment.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Low-motion fMRI data can be obtained in pediatric participants undergoing a 60-minute scan protocol.Scientific reports · 2020Trial
- Micro- and Macrostructural White Matter Integrity in Never-Treated and Currently Unmedicated Patients With Schizophrenia and Effects of Short-Term Antipsychotic Treatment.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Trial
- Experience-dependent cortical plasticity in response to formal schooling: Effects on networks for reading and mathematics.Developmental cognitive neuroscience · 2026Article
- Behavioral moderators ofFrontiers in psychiatry · 2025Article
- Impact of COVID-19 School Closures on White Matter Plasticity in the Reading Network.Neurobiology of language (Cambridge, Mass.) · 2025Article
- Testing a Home Solution for Preparing Young Children for an Awake MRI: A Promising Smartphone Application.Children (Basel, Switzerland) · 2023Article
- Initial Evidence for Positive Effects of a Psychological Preparation Program for MRI "iMReady" in Children with Neurofibromatosis Type I and Brain Tumors-How to Meet the Patients' Needs Best.Journal of clinical medicine · 2023Article
- Test-retest reliability of diffusion tensor imaging scalars in 5-year-olds.Human brain mapping · 2022Article
- Effect of number of diffusion-encoding directions in diffusion metrics of 5-year-olds using tract-based spatial statistical analysis.The European journal of neuroscience · 2022Article
- Let's Play the fMRI-Advantages of Gamified Paradigm in Examining the Motor Cortex of Young Children.Journal of clinical medicine · 2022Article
- Widespread effects of dMRI data quality on diffusion measures in children.Human brain mapping · 2022Article
- Feasibility of FreeSurfer Processing for T1-Weighted Brain Images of 5-Year-Olds: Semiautomated Protocol of FinnBrain Neuroimaging Lab.Frontiers in neuroscience · 2022Article
- Predicting multiscan MRI outcomes in children with neurodevelopmental conditions following MRI simulator training.Developmental cognitive neuroscience · 2021Article
- Development of white matter microstructure and executive functions during childhood and adolescence: a review of diffusion MRI studies.Developmental cognitive neuroscience · 2021Review
- Infant and Child MRI: A Review of Scanning Procedures.Frontiers in neuroscience · 2021Review
- Developmental Factors That Predict Head Movement During Resting-State Functional Magnetic Resonance Imaging in 3-7-Year-Old Stuttering and Non-stuttering Children.Frontiers in neuroscience · 2021Article
- Anesthesia Exposure during Therapy Predicts Neurocognitive Outcomes in Survivors of Childhood Medulloblastoma.The Journal of pediatrics · 2020Article
- Leveraging multi-shell diffusion for studies of brain development in youth and young adulthood.Developmental cognitive neuroscience · 2020Article
- Investigating the Added Value of FreeSurfer's Manual Editing Procedure for the Study of the Reading Network in a Pediatric Population.Frontiers in human neuroscience · 2020Article
- Video-based education improves the image quality of diagnostic percutaneous cerebral angiography among elderly patients.Translational neuroscience · 2020Article
Corrections and comments
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Authors and funding
3 authors.
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Abstract
Advanced Magnetic Resonance Imaging (MRI) techniques such as Diffusion Tensor Imaging (DTI) and resting-state functional MRI (rfMRI) are widely used to study structural and functional neural connectivity. However, as these techniques are highly sensitive to motion artifacts and require a considerable amount of time for image acquisition, successful acquisition of these images can be challenging to complete with certain populations. This is especially true for young children. This paper describes a new approach termed the 'submarine protocol', designed to prepare 5- and 6-year-old children for advanced MRI scanning. The submarine protocol aims to ensure that successful scans can be acquired in a time- and resource-efficient manner, without the need for sedation. This manuscript outlines the protocol and details its outcomes, as measured through the number of children who completed the scanning procedure and analysis of the degree of motion present in the acquired images. Seventy-six children aged between 5.8 and 6.9 years were trained using the submarine protocol and subsequently underwent DTI and rfMRI scanning. After completing the submarine protocol, 75 of the 76 children (99%) completed their DTI-scan and 72 children (95%) completed the full 35-minute scan session. Results of diffusion data, acquired in 75 children, showed that the motion in 60 of the scans (80%) did not exceed the threshold for excessive motion. In the rfMRI scans, this was the case for 62 of the 71 scans (87%). When placed in the context of previous studies, the motion data of the 5- and 6-year-old children reported here were as good as, or better than those previously reported for groups of older children (i.e., 8-year-olds). Overall, this study shows that the submarine protocol can be used successfully to acquire DTI and rfMRI scans in 5 and 6-year-old children, without the need for sedation or lengthy training procedures.
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