ArticleThe Journal of experimental medicine1989
Isolated human follicular dendritic cells display a unique antigenic phenotype.
Article in The Journal of experimental medicine, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 222 citations in OpenAlex.
- CD19 Isoforms Enabling Resistance to CART-19 Immunotherapy Are Expressed in B-ALL Patients at Initial Diagnosis.Journal of immunotherapy (Hagerstown, Md. : 1997) · 2017Article
- CD19 chimeric antigen receptor (CD19 CAR)-redirected adoptive T-cell immunotherapy for the treatment of relapsed or refractory B-cell Non-Hodgkin's Lymphomas.American journal of cancer research · 2016Review
- Braf mutation in interdigitating dendritic cell sarcoma: a case report and review of the literature.Cancer biology & therapy · 2015Review
- Pattern of CD14+ follicular dendritic cells and PD1+ T cells independently predicts time to transformation in follicular lymphoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2014Article
- CD40 induces anti-Toxoplasma gondii activity in nonhematopoietic cells dependent on autophagy proteins.Infection and immunity · 2013Article
- Article
- Immunotherapy for B-Cell Neoplasms using T Cells expressing Chimeric Antigen Receptors: From antigen choice to clinical implementation.Sultan Qaboos University medical journal · 2012Article
- CD40 and the immune response to parasitic infections.Seminars in immunology · 2009Review
- Foot-and-mouth disease virus can induce a specific and rapid CD4+ T-cell-independent neutralizing and isotype class-switched antibody response in naïve cattle.Journal of virology · 2009Article
- Follicular dendritic cell networks of primary follicles and germinal centers: phenotype and function.Seminars in immunology · 2008Review
- CD40-CD40L interaction in immunity against protozoan infections.Journal of biomedicine & biotechnology · 2007Article
- T-cell activation and B-cell depletion in chimpanzees treated with a bispecific anti-CD19/anti-CD3 single-chain antibody construct.Cancer immunology, immunotherapy : CII · 2006Article
- In vivo expression of interleukin-8, and regulated on activation, normal, T-cell expressed, and secreted, by human germinal centre B lymphocytes.Immunology · 2003Article
- Human follicular dendritic cells remain uninfected and capture human immunodeficiency virus type 1 through CD54-CD11a interaction.Journal of virology · 1999Article
- Two differently regulated nuclear factor kappaB activation pathways triggered by the cytoplasmic tail of CD40.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Programmed cell death: the influence of CD40, CD95 (Fas or Apo-I) and their ligands.Medical oncology (Northwood, London, England) · 1998Review
- A new mechanism of NK cell cytotoxicity activation: the CD40-CD40 ligand interaction.The Journal of experimental medicine · 1997Article
- Differentiation and apoptosis of human germinal center B-lymphocytes.Immunologic research · 1997Review
- CD40 is a prognostic marker in primary cutaneous malignant melanoma.The American journal of pathology · 1996Article
- TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
In the present study, follicular dendritic cells (FDCs) were purified to homogeneity in order to define the lineage and function of these cells. FDCs were identified by their characteristic morphology and by their expression of receptors for the third complement component, the myeloid-restricted antigen CD14, and the FDC antigen DRC-1. Unclustered FDCs displayed a unique antigenic phenotype since they expressed several B- and myeloid lineage-restricted antigens, but lacked T and NK cell antigens as well as the leukocyte common antigen. FDCs expressed adhesion molecules, including most of the VLA proteins, intercellular adhesion molecule 1 (ICAM-1), and CD11b. FDCs could be isolated to homogeneity by their intense staining with anti-CD14 using flow cytometric cell sorting. These highly purified FDCs expressed CD14 and CD21 but lacked CD20. This antigen pattern and characteristic morphology confirmed that these cells were, in fact, homogeneous FDC preparations. Analysis of polymerase chain reaction-amplified cDNA from highly purified FDCs showed no transcripts for IL-6. The isolation of homogeneous FDC populations will be important for the analysis of the functional role of FDCs within the lymphoid follicle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.