Evidence map›Paper›PMID 24717684›Full record

Trial reportPloS one2014

A randomized pilot trial of a moderate carbohydrate diet compared to a very low carbohydrate diet in overweight or obese individuals with type 2 diabetes mellitus or prediabetes.

Laura R Saslow, Sarah Kim, Jennifer J Daubenmier, Judith T Moskowitz, Stephen D Phinney, Veronica Goldman, Elizabeth J Murphy, Rachel M Cox, Patricia Moran, Fredrick M Hecht

2 registry-linked trialsOpen access · goldAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 106 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed, 15 pooled it
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01713764 phase2completednot on this map

A Pilot Study of the Effects of Diet and Behavioral Interventions on Health in Diabetics

TypeinterventionalSponsorUniversity of California, San FranciscoRan2012 to 2013Enrolled34ConditionsDiabetes Type IIArmsLow Carbohydrate Diet, American Diabetes Association Diet, Mindfulness and Positive Affect Skills
NCT04230928 nacompletednot on this mapstarted 2020, after this paper: background citation

A Pilot Study Comparing Dietary Approaches to Decrease Hypertension in a Lower Income, African American Population at Risk for Cardiovascular Disease

TypeinterventionalSponsorBaylor Research InstituteRan2020 to 2023Enrolled64ConditionsHypertension, African Americans, Diet, Carbohydrate-Restricted, Risk Reduction BehaviorArmsVery low carbohydrate diet, Standard DPP-GLB diet, Standard DPP-GLB program modules
3 · Its place in the literature

Who cites it

106 citing papers in PubMed, 15 syntheses or guidelines pooled it, 227 citations in OpenAlex.

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46 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Laura R SaslowUniversity of California San Francisco, San Francisco, California, United States of America.
Sarah KimUniversity of California San Francisco, San Francisco, California, United States of America.
Jennifer J DaubenmierUniversity of California San Francisco, San Francisco, California, United States of America.
Judith T MoskowitzUniversity of California San Francisco, San Francisco, California, United States of America.
Stephen D PhinneyUC Davis School of Medicine (Emeritus), Davis, California, United States of America.
Veronica GoldmanUniversity of California San Francisco, San Francisco, California, United States of America.
Elizabeth J MurphyUniversity of California San Francisco, San Francisco, California, United States of America.
Rachel M CoxChildren's Hospital and Research Center, Oakland, California, United States of America.
Patricia MoranUniversity of California San Francisco, San Francisco, California, United States of America.
Fredrick M HechtUniversity of California San Francisco, San Francisco, California, United States of America.
University of California, San Francisco · USUniversity of California, Davis · US

Funding

Training Researchers in Clinical Integrative Medicine (TRIM) - NOSI supplementT32AT003997 · NCCIH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SHELLEY R ADLER, MARIA T CHAO · 2007 to 2026
$6.6M
Mentoring and Research in Integrative MedicineK24AT007827 · NCCIH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HECHT, FREDERICK M · 2013 to 2022
$1.8M
Positive Affect Regulation for HIV Prevention in People with Mood DisordersK24MH093225 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MOSKOWITZ, JUDITH T. · 2011 to 2015
$713k
NCCIH NIH HHS K24 AT007827NCCIH NIH HHS T32 AT003997NCCIH NIH HHS T32AT003997NIMH NIH HHS K24 MH093225
6 · The paper itself

Abstract

We compared the effects of two diets on glycated hemoglobin (HbA1c) and other health-related outcomes in overweight or obese adults with type 2 diabetes or prediabetes (HbA1c>6%). We randomized participants to either a medium carbohydrate, low fat, calorie-restricted, carbohydrate counting diet (MCCR) consistent with guidelines from the American Diabetes Association (n = 18) or a very low carbohydrate, high fat, non calorie-restricted diet whose goal was to induce nutritional ketosis (LCK, n = 16). We excluded participants receiving insulin; 74% were taking oral diabetes medications. Groups met for 13 sessions over 3 months and were taught diet information and psychological skills to promote behavior change and maintenance. At 3 months, mean HbA1c level was unchanged from baseline in the MCCR diet group, while it decreased 0.6% in the LCK group; there was a significant between group difference in HbA1c change favoring the LCK group (-0.6%, 95% CI, -1.1% to -0.03%, p = 0.04). Forty-four percent of the LCK group discontinued one or more diabetes medications, compared to 11% of the MCCR group (p = 0.03); 31% discontinued sulfonylureas in the LCK group, compared to 5% in the MCCR group (p = 0.05). The LCK group lost 5.5 kg vs. 2.6 kg lost in MCCR group (p = 0.09). Our results suggest that a very low carbohydrate diet coupled with skills to promote behavior change may improve glycemic control in type 2 diabetes while allowing decreases in diabetes medications. This clinical trial was registered with ClinicalTrials.gov, number NCT01713764.

Indexed as

Diet, Carbohydrate-RestrictedBlood GlucoseBody WeightDemographyDiabetes Mellitus, Type 2FastingFemaleGlycated HemoglobinHumansMaleMiddle AgedObesityPrediabetic StateTriglyceridesBlood GlucoseGlycated HemoglobinTriglycerides

Identifiers

PMID24717684
PMCPMC3981696
OpenAlexW2035829927

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.