ReviewCurrent opinion in cardiology2014
Genetic testing in cardiovascular diseases.
Review in Current opinion in cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01736566 (The MedSeq Project Pilot Study), which is not on this map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The MedSeq Project Pilot Study: Integrating Whole Genome Sequencing Into the Practice of Clinical Medicine
Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Cardiology clinic patient attitudes toward and potential personal utility of genetic testing: Findings from a unique multiracial clinical sample.Journal of genetic counseling · 2022Article
- Compendium of causative genes and their encoded proteins for common monogenic disorders.Protein science : a publication of the Protein Society · 2022Article
- Heritability and genome-wide association study of blood pressure in Chinese adult twins.Molecular genetics & genomic medicine · 2021Article
- Clinical and genetic spectrum of neonatal arrhythmia in a NICU.Translational pediatrics · 2021Article
- Vascular Genetics: Presentations, Testing, and Prognostics.Current treatment options in cardiovascular medicine · 2018Review
- The developmental origin of heart size and shape differences in Astyanax mexicanus populations.Developmental biology · 2018Article
- IDENTIFYING NEW SUDDEN DEATH GENES.Transactions of the American Clinical and Climatological Association · 2018Article
- Whole gene sequencing identifies deep-intronic variants with potential functional impact in patients with hypertrophic cardiomyopathy.PloS one · 2017Article
- Genetics of congenital heart disease.Current opinion in cardiology · 2016Review
- Gene scanning and heart attack risk.Trends in cardiovascular medicine · 2016Review
- Utility and limitations of exome sequencing as a genetic diagnostic tool for conditions associated with pediatric sudden cardiac arrest/sudden cardiac death.Human genomics · 2015Article
- Personalized biochemistry and biophysics.Biochemistry · 2015Article
- The genetic landscape of cardiomyopathy and its role in heart failure.Cell metabolism · 2015Review
- Advances in the treatment of aortic valve disease: is it time for companion diagnostics?Current opinion in pediatrics · 2014Review
- Cardiovascular genetics: paying individual dividends.Science translational medicine · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
purpose of reviewThe review is designed to outline the major developments in genetic testing in the cardiovascular arena in the past year or so. This is an exciting time in genetic testing as whole exome and whole genome approaches finally reach the clinic. These new approaches offer insight into disease causation in families in which this might previously have been inaccessible, and also bring a wide range of interpretative challenges. RECENT
findingsAmong the most significant recent findings has been the extent of physiologic rare coding variation in the human genome. New disease genes have been identified through whole exome studies in neonatal arrhythmia, congenital heart disease and coronary artery disease that were simply inaccessible with other techniques. This has not only shed light on the challenges of genetic testing at this scale, but has also sharply defined the limits of prior gene-panel focused testing. As novel therapies targeting specific genetic subsets of disease become available, genetic testing will become a part of routine clinical care. SUMMARY: The pace of change in sequencing technologies has begun to transform clinical medicine, and cardiovascular disease is no exception. The complexity of such studies emphasizes the importance of real-time communication between the genetics laboratory and genetically informed clinicians. New efforts in data and knowledge management will be central to the continued advancement of genetic testing.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.