ArticlePloS one2014
Highly effective photonic cue for repulsive axonal guidance.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Implication of thermal signaling in neuronal differentiation revealed by manipulation and measurement of intracellular temperature.Nature communications · 2024Article
- Neurite regrowth stimulation by a red-light spot focused on the neuronal cell soma following blue light-induced retraction.Scientific reports · 2019Article
- Spatial temperature gradients guide axonal outgrowth.Scientific reports · 2016Article
- Optogenetic activation of axon guidance receptors controls direction of neurite outgrowth.Scientific reports · 2016Article
- Triggering of high-speed neurite outgrowth using an optical microheater.Scientific reports · 2015Article
- Loop formation and self-fasciculation of cortical axon using photonic guidance at long working distance.Scientific reports · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In vivo nerve repair requires not only the ability to regenerate damaged axons, but most importantly, the ability to guide developing or regenerating axons along paths that will result in functional connections. Furthermore, basic studies in neuroscience and neuro-electronic interface design require the ability to construct in vitro neural circuitry. Both these applications require the development of a noninvasive, highly effective tool for axonal growth-cone guidance. To date, a myriad of technologies have been introduced based on chemical, electrical, mechanical, and hybrid approaches (such as electro-chemical, optofluidic flow and photo-chemical methods). These methods are either lacking in desired spatial and temporal selectivity or require the introduction of invasive external factors. Within the last fifteen years however, several attractive guidance cues have been developed using purely light based cues to achieve axonal guidance. Here, we report a novel, purely optical repulsive guidance technique that uses low power, near infrared light, and demonstrates the guidance of primary goldfish retinal ganglion cell axons through turns of up to 120 degrees and over distances of ∼90 µm.
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Registered trials
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