Evidence map›Paper›PMID 24717072›Full record

ArticleACS nano2014

Near-infrared-induced heating of confined water in polymeric particles for efficient payload release.

Mathieu L Viger, Wangzhong Sheng, Kim Doré, Ali H Alhasan, Carl-Johan Carling, Jacques Lux, Caroline de Gracia Lux, Madeleine Grossman, Roberto Malinow, Adah Almutairi

Abstract read
In one paragraph

Article in ACS nano, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Near-infrared hyperspectral imaging for predicting the quality of SOJournal of food science and technology · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Light-responsive biomaterials for ocular drug delivery.Drug delivery and translational research · 2023
    Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. ACS central science · 2017
    Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mathieu L VigerSkaggs School of Pharmacy and Pharmaceutical Sciences, ‡Department of Mechanical and Aerospace Engineering, Materials Science and Engineering Program, §Center for Neural Circuits and Behavior, Division of Biology, Department of Neuroscience and Section of Neurobiology, ⊥Department of Chemistry and Biochemistry, and ∥KACST-UCSD Center of Excellence in Nanomedicine, University of California, San Diego , 9500 Gilman Drive, La Jolla, California 92093-0600, United States.
Wangzhong Sheng
Kim Doré
Ali H Alhasan
Carl-Johan Carling
Jacques Lux
Caroline de Gracia Lux
Madeleine Grossman
Roberto Malinow
Adah Almutairi

Funding

MECHANISMS OF SYNAPTIC LTP--SILENT SYNAPSESR01MH049159 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALINOW, ROBERTO · 1997 to 2019
$4.7M
Novel roles by glutamatergic receptors in the synaptic effects of beta amyloidR01AG032132 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALINOW, ROBERTO · 2008 to 2017
$4.5M
A Synaptic Locus Controlling Behavioral DepressionR01MH091119 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALINOW, ROBERTO · 2011 to 2020
$3.9M
Chemically amplified response strategies for medical sciences; concepts borrowedDP2OD006499 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ALMUTAIRI, ADAH · 2009 to 2009
$2.3M
NIA NIH HHS R01 AG032132NIA NIH HHS R01AG032132NIH HHS 1 DP2 OD006499-01NIH HHS DP2 OD006499NIMH NIH HHS R01 MH049159NIMH NIH HHS R01 MH091119
6 · The paper itself

Abstract

Near-infrared (NIR) light-triggered release from polymeric capsules could make a major impact on biological research by enabling remote and spatiotemporal control over the release of encapsulated cargo. The few existing mechanisms for NIR-triggered release have not been widely applied because they require custom synthesis of designer polymers, high-powered lasers to drive inefficient two-photon processes, and/or coencapsulation of bulky inorganic particles. In search of a simpler mechanism, we found that exposure to laser light resonant with the vibrational absorption of water (980 nm) in the NIR region can induce release of payloads encapsulated in particles made from inherently non-photo-responsive polymers. We hypothesize that confined water pockets present in hydrated polymer particles absorb electromagnetic energy and transfer it to the polymer matrix, inducing a thermal phase change. In this study, we show that this simple and highly universal strategy enables instantaneous and controlled release of payloads in aqueous environments as well as in living cells using both pulsed and continuous wavelength lasers without significant heating of the surrounding aqueous solution.

Indexed as

Spectroscopy, Near-InfraredAnimalsDrug CarriersHepatocytesHumansHydrogelsLactic AcidLasersLightMacrophagesPhotochemistryPhotonsPolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerPolymersSpectrometry, FluorescenceDrug CarriersHydrogelsLactic AcidPolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerPolymersWater

Identifiers

PMID24717072
PMCPMC4046803

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.