ReviewExpert review of clinical pharmacology2014
Combination pharmacotherapies for stimulant use disorder: a review of clinical findings and recommendations for future research.
Review in Expert review of clinical pharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 34 citations in OpenAlex.
- Naltrexone plus bupropion reduces cigarette smoking in individuals with methamphetamine use disorder: A secondary analysis from the CTN ADAPT-2 trial.Journal of substance use and addiction treatment · 2023Trial
- Naltrexone-bupropion combinations do not affect cocaine self-administration in humans.Pharmacology, biochemistry, and behavior · 2023Trial
- Emerging medications and pharmacological treatment approaches for substance use disorders.Pharmacology, biochemistry, and behavior · 2025Review
- Therapeutic targeting of neuroinflammation in methamphetamine use disorder.Future medicinal chemistry · 2025Review
- A synergistic effect of herb and acupuncture on the methamphetamine.Integrative medicine research · 2024Article
- Novel therapeutics in development for the treatment of stimulant-use disorder.Current opinion in neurobiology · 2024Review
- Pharmacotherapy treatment of stimulant use disorder.The mental health clinician · 2021Article
- Pharmacotherapeutic strategies for treating cocaine use disorder-what do we have to offer?Addiction (Abingdon, England) · 2021Article
- Tryptophan degradation is associated with risk-taking propensity in methamphetamine users with treated HIV infection.Journal of neurovirology · 2020Article
- Executive function moderates naltrexone effects on methamphetamine-induced craving and subjective responses.The American journal of drug and alcohol abuse · 2020Article
- Effects of voluntary exercise and sex on multiply-triggered heroin reinstatement in male and female rats.Psychopharmacology · 2020Article
- Retrospective analysis of health claims to evaluate pharmacotherapies with potential for repurposing: Association of bupropion and stimulant use disorder remission.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2018Article
- The individual and combined effects of phenmetrazine and mgluR2/3 agonist LY379268 on the motivation to self-administer cocaine.Drug and alcohol dependence · 2016Article
- How to study sex differences in addiction using animal models.Addiction biology · 2016Review
- Sex and menstrual cycle effects on chronic oral cocaine self-administration in rhesus monkeys: Effects of a nondrug alternative reward.Psychopharmacology · 2016Article
- Sex differences in the reduction of impulsive choice (delay discounting) for cocaine in rats with atomoxetine and progesterone.Psychopharmacology · 2016Article
- Amphetamine elevates nucleus accumbens dopamine via an action potential-dependent mechanism that is modulated by endocannabinoids.The European journal of neuroscience · 2016Article
- Sex differences in reinstatement of cocaine-seeking with combination treatments of progesterone and atomoxetine.Pharmacology, biochemistry, and behavior · 2016Article
- Separate and Combined Effects of Naltrexone and Extended-Release Alprazolam on the Reinforcing, Subject-Rated, and Cardiovascular Effects of Methamphetamine.Journal of clinical psychopharmacology · 2016Article
- Long-Term Blockade of Cocaine Self-Administration and Locomotor Activation in Rats by an Adenoviral Vector-Delivered Cocaine Hydrolase.The Journal of pharmacology and experimental therapeutics · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Despite concerted efforts to identify a pharmacotherapy for managing stimulant use disorders, no widely effective medications have been approved. Innovative strategies are necessary to develop successful pharmacotherapies for stimulant use disorders. This manuscript reviews human laboratory studies and clinical trials to determine whether one such strategy, use of combination pharmacotherapies, holds promise. The extant literature shows that combination pharmacotherapy produced results that were better than placebo treatment, especially with medications shown to have efficacy as monotherapies. However, many studies did not compare individual constituents to the combination treatment, making it impossible to determine whether combination treatment is more effective than monotherapy. Future research should systematically compare combined treatments with individual agents using medications showing some efficacy when tested alone.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.