ArticleClinical toxicology (Philadelphia, Pa.)2014
The vitamin B12 analog cobinamide is an effective hydrogen sulfide antidote in a lethal rabbit model.
Article in Clinical toxicology (Philadelphia, Pa.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT03783091 (A Phase II Double Blind Randomized Controlled Trial of High Dose Vitamin B12 in Septic Shock), which is not on this map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Phase II Double Blind Randomized Controlled Trial of High Dose Vitamin B12 in Septic Shock
Who cites it
19 citing papers in PubMed, 51 citations in OpenAlex.
- Neutralization of reactive oxygen species with cobinamide augments aortic dissections and rupture in BAPN-administered mice.American journal of physiology. Heart and circulatory physiology · 2026Article
- Neurological Sequelae of Acute Hydrogen Sulfide Poisoning: A Literature Review, Controversies, and Knowledge Gaps.Neurology international · 2025Review
- Essential role of sulfide oxidation in brain health and neurological disorders.Pharmacology & therapeutics · 2025Review
- Methyl mercaptan gas: mechanisms of toxicity and demonstration of the effectiveness of cobinamide as an antidote in mice and rabbits.Clinical toxicology (Philadelphia, Pa.) · 2022Article
- Methods for Suppressing Hydrogen Sulfide in Biological Systems.Antioxidants & redox signaling · 2022Review
- The Potential Role of Hydrogen Sulfide in the Regulation of Cerebrovascular Tone.Biomolecules · 2020Review
- Emerging pharmacological tools to control hydrogen sulfide signaling in critical illness.Intensive care medicine experimental · 2020Review
- Hydrogen Sulfide Toxicity: Mechanism of Action, Clinical Presentation, and Countermeasure Development.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2019Review
- Data-Driven Identification of Hydrogen Sulfide Scavengers.Angewandte Chemie (International ed. in English) · 2019Article
- Methylene Blue Administration During and After Life-Threatening Intoxication by Hydrogen Sulfide: Efficacy Studies in Adult Sheep and Mechanisms of Action.Toxicological sciences : an official journal of the Society of Toxicology · 2019Article
- Environmental toxicology of hydrogen sulfide.Nitric oxide : biology and chemistry · 2017Review
- Comparative studies of reaction of cobalamin (II) and cobinamide (II) with sulfur dioxide.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2017Article
- Oral Glycine and Sodium Thiosulfate for Lethal Cyanide Ingestion.Journal of clinical toxicology · 2017Article
- Development of a Hydrogen Sulfide End-of-Service-Life Indicator for Respirator Cartridges Using Cobinamide.Sensors and actuators. B, Chemical · 2016Article
- Hydrogen Sulfide--Mechanisms of Toxicity and Development of an Antidote.Scientific reports · 2016Article
- Decellularized skeletal muscle as an in vitro model for studying drug-extracellular matrix interactions.Biomaterials · 2015Article
- Cardiogenic shock induced reduction in cellular O2 delivery as a hallmark of acute H2S intoxication.Clinical toxicology (Philadelphia, Pa.) · 2015Article
- High-dose hydroxocobalamin administered after H2S exposure counteracts sulfide-poisoning-induced cardiac depression in sheep.Clinical toxicology (Philadelphia, Pa.) · 2015Article
- Are H2S-trapping compounds pertinent to the treatment of sulfide poisoning?Clinical toxicology (Philadelphia, Pa.) · 2014Article
Corrections and comments
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- Erratum issued
Authors and funding
13 authors at 4 institutions in 1 country.
Funding
Abstract
background and purposeHydrogen sulfide (H2S) is a highly toxic gas for which no effective antidotes exist. It acts, at least in part, by binding to cytochrome c oxidase, causing cellular asphyxiation and anoxia. We investigated the effects of three different ligand forms of cobinamide, a vitamin B12 analog, to reverse sulfide (NaHS) toxicity.
methodsNew Zealand white rabbits received a continuous intravenous (IV) infusion of NaHS (3 mg/min) until expiration or a maximum 270 mg dose. Animals received six different treatments, administered at the time when they developed signs of severe toxicity: Group 1-saline (placebo group, N = 9); Group 2--IV hydroxocobalamin (N = 7); Group 3--IV aquohydroxocobinamide (N = 6); Group 4--IV sulfitocobinamide (N = 6); Group 5--intramuscular (IM) sulfitocobinamide (N = 6); and Group 6-IM dinitrocobinamide (N = 8). Blood was sampled intermittently, and systemic blood pressure and deoxygenated and oxygenated hemoglobin were measured continuously in peripheral muscle and over the brain region; the latter were measured by diffuse optical spectroscopy (DOS) and continuous wave near infrared spectroscopy (CWNIRS).
resultsCompared with the saline controls, all cobinamide derivatives significantly increased survival time and the amount of NaHS that was tolerated. Aquohydroxocobinamide was most effective (261.5 ± 2.4 mg NaHS tolerated vs. 93.8 ± 6.2 mg in controls, p < 0.0001). Dinitrocobinamide was more effective than sulfitocobinamide. Hydroxocobalamin was not significantly more effective than the saline control.
conclusionsCobinamide is an effective agent for inhibiting lethal sulfide exposure in this rabbit model. Further studies are needed to determine the optimal dose and form of cobinamide and route of administration.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.