ArticleACS applied materials & interfaces2014
Thermoresponsive magnetic hydrogels as theranostic nanoconstructs.
Article in ACS applied materials & interfaces, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Smart responsive hydrogels combined with AI design for tumor therapy.Acta pharmaceutica Sinica. B · 2026Review
- Functional hydrogel biomaterials for urological diagnosis and treatment-design strategies and application progress: a review.Journal of materials science. Materials in medicine · 2026Review
- Multifunctional Hydrogels for Advanced Cancer Treatment: Diagnostic Imaging and Therapeutic Modalities.Gels (Basel, Switzerland) · 2025Review
- Smart Nanocomposite Hydrogels as Next-Generation Therapeutic and Diagnostic Solutions.Gels (Basel, Switzerland) · 2024Review
- Ultrasound and x-ray imageable poloxamer-based hydrogel for loco-regional therapy delivery in the liver.Scientific reports · 2024Article
- Ultrasound and x-ray imageable poloxamer-based hydrogel for loco-regional therapy delivery in the liver.Research square · 2024Article
- Stiffness assisted cell-matrix remodeling trigger 3D mechanotransduction regulatory programs.Biomaterials · 2024Article
- Review
- Nanoparticles for Magnetic Heating: When Two (or More) Is Better Than One.Materials (Basel, Switzerland) · 2021Review
- Superparamagnetic Iron Oxide Nanoparticles and Essential Oils: A New Tool for Biological Applications.International journal of molecular sciences · 2020Review
- Magnetic Dehydrodipeptide-Based Self-Assembled Hydrogels for Theragnostic Applications.Nanomaterials (Basel, Switzerland) · 2019Article
- Hierarchy of Hybrid Materials-The Place of Inorganics-Frontiers in chemistry · 2019Review
- Influence of Grafted Block Copolymer Structure on Thermoresponsiveness of Superparamagnetic Core-Shell Nanoparticles.Biomacromolecules · 2018Article
- Magnetic Poly(N-isopropylacrylamide) Nanocomposites: Effect of Preparation Method on Antibacterial Properties.Nanoscale research letters · 2017Article
- Injectable nanoengineered stimuli-responsive hydrogels for on-demand and localized therapeutic delivery.Nanoscale · 2017Article
- Synergistically enhanced selective intracellular uptake of anticancer drug carrier comprising folic acid-conjugated hydrogels containing magnetite nanoparticles.Scientific reports · 2017Article
- Photothermal-modulated drug delivery and magnetic relaxation based on collagen/poly(γ-glutamic acid) hydrogel.International journal of nanomedicine · 2017Article
- Nanoengineered thermoresponsive magnetic hydrogels for biomedical applications.Bioengineering & translational medicine · 2016Review
- Magnetic nanoparticles and nanocomposites for remote controlled therapies.Journal of controlled release : official journal of the Controlled Release Society · 2015Review
- Effect of nitro-functionalization on the cross-linking and bioadhesion of biomimetic adhesive moiety.Biomacromolecules · 2015Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
We report the development of thermoresponsive magnetic hydrogels based on poly(N-isopropylacrylamide) encapsulation of Fe3O4 magnetic nanostructures (MNS). In particular, we examined the effects of hydrogels encapsulated with poly-ethylene glycol (PEG) and polyhedral oligomeric silsesquioxane (POSS) surface modified Fe3O4 MNS on magnetic resonance (MR) T2 (transverse spin relaxation) contrast enhancement and associated delivery efficacy of absorbed therapeutic cargo. The microstructural characterization reveal the regular spherical shape and size (∼200 nm) of the hydrogels with elevated hydrophilic to hydrophobic transition temperature (∼40 °C) characterized by LCST (lower critical solution temperature) due to the presence of encapsulated MNS. The hydrogel-MNS (HGMNS) system encapsulated with PEG functionalized Fe3O4 of 12 nm size (HGMNS-PEG-12) exhibited relaxivity rate (r2) of 173 mM(-1) s(-1) compared to 129 mM(-1) s(-1) obtained for hydrogel-MNS system encapsulated with POSS functionalized Fe3O4 (HGMNS-POSS-12) of the same size. Further studies with HGMNS-PEG-12 with absorbed drug doxorubicin (DOX) reveals approximately two-fold enhance in release during 1 h RF (radio-frequency) field exposure followed by 24 h incubation at 37 °C. Quantitatively, it is 2.1 μg mg(-1) (DOX/HGMNS) DOX release with RF exposure while only 0.9 μg mg(-1) release without RF exposure for the same period of incubation. Such enhanced release of therapeutic cargo is attributed to micro-environmental heating in the surroundings of MNS as well as magneto-mechanical vibrations under high frequency RF inside hydrogels. Similarly, RF-induced in vitro localized drug delivery studies with HeLa cell lines for HGMNS-PEG-12 resulted in more than 80% cell death with RF field exposures for 1 h. We therefore believe that magnetic hydrogel system has in vivo theranostic potential given high MR contrast enhancement from encapsulated MNS and RF-induced localized therapeutic delivery in one nanoconstruct.
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Registered trials
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