ReviewJournal of traditional and complementary medicine2013
A Systematic Review of the Mysterious Caterpillar Fungus Ophiocordyceps sinensis in Dong-ChongXiaCao ( Dōng Chóng Xià Cǎo) and Related Bioactive Ingredients.
Review in Journal of traditional and complementary medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed.
- Discovery of functional compounds from dimorphic edibleSynthetic and systems biotechnology · 2026Article
- Identification of geographical origins of Ophiocordyceps sinensis (Berk.) via machine learning-assisted surface-enhanced Raman spectroscopy.Analytical and bioanalytical chemistry · 2026Article
- Pleiotropic Bioactivity of Caterpillar Fungus, Orange Cordyceps, and Cordycepin: Insight from Integrated Network Pharmacology and Food and Drug Regulatory Framework.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Article
- A cross-kingdom metabolite signal: tryptophan fromFrontiers in microbiology · 2026Article
- The Conservation Crisis ofJournal of fungi (Basel, Switzerland) · 2025Review
- Whole genome sequencing and resequencing provide insight into the genetic structure of wild Ophiocordyceps sinensis.BMC genomics · 2025Article
- Article
- Untargeted Metabolomics-Based Characterization of the Metabolic Profile and Antioxidant Activity ofJournal of fungi (Basel, Switzerland) · 2025Article
- Integrated Proteomics and Metabolomics Reveal Regulatory Pathways Underlying Quality Differences Between Wild and CultivatedJournal of fungi (Basel, Switzerland) · 2025Article
- Sustainable cultivation of phytopharmaceuticals in Baden-Wuerttemberg, Germany: a SWOT analysis and future directions.Pharmaceutical biology · 2025Article
- Article
- Uncovering proteome variations and concomitant quality changes of different drying methodsFrontiers in nutrition · 2025Article
- Edible mushrooms trending in food: Nutrigenomics, bibliometric, from bench to valuable applications.Heliyon · 2024Review
- The Anti-Inflammatory Effects and Mechanism of the Submerged Culture ofJournal of fungi (Basel, Switzerland) · 2024Article
- Comparative Cytotoxicity Evaluation of Heat-AssistedFood technology and biotechnology · 2024Article
- Rapid discrimination between wild and cultivatedCurrent research in food science · 2024Article
- Mannitol mediates the mummification behavior ofFrontiers in microbiology · 2024Article
- Two new diketopiperazines from the Cordyceps fungus Samsoniella sp. XY4.The Journal of antibiotics · 2023Article
- Characterization of Metabolite Landscape Distinguishes Medicinal FungusMolecules (Basel, Switzerland) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The caterpillar fungus Ophiocordyceps sinensis (syn.Cordyceps sinensis), which was originally used in traditional Tibetan and Chinese medicine, is called either "yartsa gunbu" or "DongChongXiaCao ( Dōng Chóng Xià Cǎo)" ("winter worm-summer grass"), respectively. The extremely high price of DongChongXiaCao, approximately USD $20,000 to 40,000 per kg, has led to it being regarded as "soft gold" in China. The multi-fungi hypothesis has been proposed for DongChongXiaCao; however, Hirsutella sinensis is the anamorph of O. sinensis. In Chinese, the meaning of "DongChongXiaCao" is different for O. sinensis, Cordyceps spp., and Cordyceps sp. Over 30 bioactivities, such as immunomodulatory, antitumor, anti-inflammatory, and antioxidant activities, have been reported for wild DongChongXiaCao and for the mycelia and culture supernatants of O. sinensis. These bioactivities derive from over 20 bioactive ingredients, mainly extracellular polysaccharides, intracellular polysaccharides, cordycepin, adenosine, mannitol, and sterols. Other bioactive components have been found as well, including two peptides (cordymin and myriocin), melanin, lovastatin, γ-aminobutyric acid, and cordysinins. Recently, the bioactivities of O. sinensis were described, and they include antiarteriosclerosis, antidepression, and antiosteoporosis activities, photoprotection, prevention and treatment of bowel injury, promotion of endurance capacity, and learning-memory improvement. H. sinensis has the ability to accelerate leukocyte recovery, stimulate lymphocyte proliferation, antidiabetes, and improve kidney injury. Starting January 1(st), 2013, regulation will dictate that one fungus can only have one name, which will end the system of using separate names for anamorphs. The anamorph name "H. sinensis" has changed by the International Code of Nomenclature for algae, fungi, and plants to O. sinensis.
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