ArticleCase reports in oncological medicine2014
Clear cell adenocarcinoma of the colon: a case report and review of the literature.
Article in Case reports in oncological medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Alpha-fetoprotein elevation in an asymptomatic young adult as a diagnostic clue to colorectal adenocarcinoma with enteroblastic differentiation.Clinical journal of gastroenterology · 2026Article
- Colorectal clear cell carcinoma: a literature review.Journal of medical case reports · 2025Review
- Colorectal adenocarcinoma with clear cell changes: immunohistological and molecular findings in three cases.Virchows Archiv : an international journal of pathology · 2024Article
- Mucinous Adenocarcinoma of the Colon with Clear Cell Component: A Case Report and Literature Review.Case reports in pathology · 2022Article
- Early stage clear cell adenocarcinoma coexisting with tubular adenoma and adenoma with clear cell change in the colon.Clinical journal of gastroenterology · 2021Article
- Incidental morphological findings in colorectal adenomas.Histopathology · 2021Review
- Review
- Colon adenoma and adenocarcinoma with clear cell components - two case reports.Diagnostic pathology · 2019Article
- Early stage clear cell adenocarcinoma of the colon examined in detail with image-enhanced endoscopy: a case report.Clinical journal of gastroenterology · 2018Article
- Right Colon Clear Cell Carcinoma of Müllerian Type.Case reports in gastroenterologyArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clear cell adenocarcinoma of the colon has been described scarcely in the literature. It affects elderly men more commonly than women and usually appears in the left side of the colon. A Hispanic 41-year-old female came to the emergency room with abdominal pain, vomiting, and distension. Physical exam revealed generalized tenderness without peritoneal signs. Laboratory data was unremarkable. A CT scan showed an apple-core lesion in the distal colon. A flexible sigmoidoscopy revealed an obstructive mass that made further evaluation impossible. Exploratory surgery revealed a hard mass obstructing the descending colon, which was resected. Histopathology analysis with immunohistochemistry staining was positive for cytokeratin 20, cytokeratin 10, CDX2, and villin, while it was negative for cytokeratin 7, RCC, vimentin, and CD31. These results confirmed the clear cell variant of the adenocarcinoma. Clear cell adenocarcinomas usually arise from the kidneys and Müllerian organs. Immunohistochemistry is crucial for establishing the origin of these neoplastic cells. A cytokeratin 20+/7- with positive CDX2 is highly specific and sensitive for intestinal neoplastic origin. The main treatment has been surgery alone with moderately good results. More research and information about this malignancy is needed, especially in regard to prognosis and in order to provide the best treatment option.
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Registered trials
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