Trial reportJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2014
Cardiovascular implantable electronic device infection: delayed vs standard FDG PET-CT imaging.
Trial report in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02196753 (Positron Emission Tomography Combined With Computed Tomography), which is not on this map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Positron Emission Tomography Combined With Computed Tomography (PET CT) in Suspected Cardiovascular Implantable Electronic Device Infection, a Pilot Study - PET Guidance I
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- EANM/SNMMI guideline/procedure standard for [European journal of nuclear medicine and molecular imaging · 2025Guideline
- Role ofJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Pooled it
- Expert consensus on workflow of PET/CT with long axial field-of-view.European journal of nuclear medicine and molecular imaging · 2025Review
- Contemporary Role of Positron Emission Tomography (PET) in Endocarditis: A Narrative Review.Journal of clinical medicine · 2024Review
- Dual-Time-Point 18F-FDG PET/CT in Infective Endocarditis: Impact of Delayed Imaging in the Definitive Diagnosis of Endocarditis.Biomedicines · 2024Article
- The Role of theJournal of personalized medicine · 2024Article
- Multimodality Imaging Diagnosis in Infective Endocarditis.Life (Basel, Switzerland) · 2023Review
- Advances in Molecular Imaging in Infective Endocarditis.Vaccines · 2023Review
- Accuracy ofJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Nuclear Imaging in Infective Endocarditis.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- The Diagnostic Value of 99mTc-HMPAO-Labelled White Blood Cell Scintigraphy and 18F-FDG PET/CT in Cardiac Device-Related Infective Endocarditis-A Systematic Review.Journal of personalized medicine · 2021Review
- Review
- Procedural recommendations of cardiac PET/CT imaging: standardization in inflammatory-, infective-, infiltrative-, and innervation (4Is)-related cardiovascular diseases: a joint collaboration of the EACVI and the EANM.European journal of nuclear medicine and molecular imaging · 2021Article
- State of the art ofClinical and translational imaging · 2021Review
- Procedural recommendations of cardiac PET/CT imaging: standardization in inflammatory-, infective-, infiltrative-, and innervation- (4Is) related cardiovascular diseases: a joint collaboration of the EACVI and the EANM: summary.European heart journal. Cardiovascular Imaging · 2020Article
- Clinical value of FDG-PET/CT in bacteremia of unknown origin with catalase-negative gram-positive cocci or Staphylococcus aureus.European journal of nuclear medicine and molecular imaging · 2019Article
- Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- Cardiac Implantable Electronic Device-Related Infection Due toOpen forum infectious diseases · 2019Article
- Dual-time-point FDG PET/CT imaging in prosthetic heart valve endocarditis.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPositron emission tomography-computed tomography (PET-CT) with (18)F-fluorodeoxyglucose (FDG) has emerged as a rapidly evolving diagnostic tool for infectious diseases. However, the optimal imaging time in this clinical setting is not clear yet. The aim of this study is to investigate whether delayed (3 hours) FDG PET-CT could increase the diagnostic accuracy of this technique compared to standard (1 hour) imaging in the detection of septic foci involving the pocket and/or pacing leads in patients with suspected cardiovascular implantable electronic device (CIED) infection scheduled for device removal. METHODS AND
resultsTwenty-seven patients underwent standard and delayed imaging. PET-CT results were compared to bacteriological cultures after CIED removal. Fifteen controls free of infection underwent PET-CT imaging as part of investigation of malignancy. The diagnostic accuracy of delayed imaging was significantly higher than 1-hour scan for lead infection (70% vs 51%, P = .024). No significant difference was found between standard and delayed diagnostic accuracy for pocket or device infection. Semi-quantitative analysis showed that mean pocket and lead target-to-background ratio were significantly higher on delayed compared to standard imaging (3.7 ± 1.9 vs 1.6 ± 1.1, P = .0002; 3.0 ± 1.3 vs 0.7 ± 1.0, P = .01).
conclusionsDelayed FDG PET-CT imaging should be considered at least in patients with negative 1-hour scan and founded suspicion of pacing lead infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.