ReviewCurrent pain and headache reports2014
Licit and illicit drug use in cluster headache.
Review in Current pain and headache reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Smoking in primary headaches - a systematic review and meta-analysis.The journal of headache and pain · 2025Pooled it
- Self-Reported Efficacy of Treatments in Cluster Headache: a Systematic Review of Survey Studies.Current pain and headache reports · 2022Pooled it
- Risk and reward seeking behaviour in episodic cluster headache - a psychometric and behavioural study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Evaluation of Personality Profiles in Cluster Headache Patients: A Comparative Analysis with Migraine Patients Using the Minnesota Multiphasic Personality Inventory-3.Journal of clinical medicine · 2025Article
- 15. Cluster Headache.Pain practice : the official journal of World Institute of Pain · 2025Review
- Smoking and cluster headache presentation and responsiveness to treatment.BMC neurology · 2024Article
- Ketamine as Treatment for Cluster Headache: A Systematic Review of Literature and a Case Series.Pain and therapy · 2024Article
- Cocaine-Induced Headache: A Review of Pathogenesis, Presentation, Diagnosis, and Management.Cureus · 2020Review
- Pharmacotherapy for Cluster Headache.CNS drugs · 2020Review
- Lifestyle Modifications to Help Prevent Headache at a Developmental Age.Frontiers in neurology · 2020Review
- Behavioral and psychological aspects of cluster headache: an overview.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Review
- Increased use of illicit drugs in a Dutch cluster headache population.Cephalalgia : an international journal of headache · 2019Article
- Emerging relevance of circadian rhythms in headaches and neuropathic pain.Acta physiologica (Oxford, England) · 2019Review
- Clinical Characteristics and Treatment Patterns Among Patients Diagnosed With Cluster Headache in U.S. Healthcare Claims Data.Headache · 2017Observational
- Psychoactive substances as a last resort-a qualitative study of self-treatment of migraine and cluster headaches.Harm reduction journal · 2017Article
- Psychedelic and nonpsychedelic LSD and psilocybin for cluster headache.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cluster headache patients seem to use more licit and illicit substances than the general population. The epidemiologic data supporting this is growing. We included the licit drugs in this review because their use seems to be driven by the same addiction mechanisms leading to illicit drug abuse. Some drugs may be used in an attempt to treat cluster headache, especially cocaine and hallucinogens. Drug exposure may also play a role in CH pathophysiology, as suggested by interesting data on tobacco use and second-hand smoke exposure. A common factor may contribute both to CH and drug use predisposition. Genetic factors may be at play, and the dopaminergic and orexinergic pathways could be targeted for future studies.
Indexed as
Identifiers
24715619What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.